Pervasive hybridization with local wild relatives in Western European grapevine varieties.

Grapevine ( L.) diversity richness results from a complex domestication history over multiple historical periods. Here, we used whole-genome resequencing to elucidate different aspects of its recent evolutionary history.

Changes in nerve conduction studies predate clinical symptoms onset in early onset Val30Met hereditary ATTR amyloidosis.

Background And Purpose: Hereditary amyloidosis related to transthyretin (ATTR) is a rare and progressive disease that, despite the phenotypic heterogeneity, a length-dependent sensorimotor axonal neuropathy (ATTR-PN) is the classic hallmark. Timely diagnosis is paramount for early treatment implementation.

Methods: Sixty-nine asymptomatic gene carriers (Val30Met) were assessed during a 4-year period to identify those remaining asymptomatic versus those converting to ATTRV30M-PN.

Contamination gradient affects differently carbonic anhydrase activity of mollusks depending on their feeding habits.

Aquatic organisms that inhabit coastal areas are often exposed to several contaminants. It is known that the bioaccumulation of contaminants can be amplified according to the species feeding habits and contaminant properties. As a consequence, species can experience different effects to contaminant exposure even if they inhabit the same area.

Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis.

In emergency myelopoiesis (EM), expansion of the myeloid progenitor compartment and increased myeloid cell production are observed and often mediated by the pro-inflammatory cytokine interferon gamma (IFN-γ). Interleukin-10 (IL-10) inhibits IFN-γ secretion, but paradoxically, its therapeutic administration to humans causes hematologic changes similar to those observed in EM. In this work, we use different in vivo systems, including a humanized immune system mouse model, to show that IL-10 triggers EM, with a significant expansion of the myeloid progenitor compartment and production of myeloid cells.

Capacitively-Coupled ECG and Respiration for Sleep-Wake Prediction and Risk Detection in Sleep Apnea Patients.

Obstructive sleep apnea (OSA) patients would strongly benefit from comfortable home diagnosis, during which detection of wakefulness is essential. Therefore, capacitively-coupled electrocardiogram (ccECG) and bioimpedance (ccBioZ) sensors were used to record the sleep of suspected OSA patients, in parallel with polysomnography (PSG). The three objectives were quality assessment of the unobtrusive signals during sleep, prediction of sleep-wake using ccECG and ccBioZ, and detection of high-risk OSA patients.

Association of vitamin A with anemia and serum hepcidin levels in children aged 6 to 59 mo.

Objective: This study evaluates the association of serum retinol, hepcidin levels, and anemia in children.

Methods: This cross-sectional study included 312 children, ages 6 to 59 mo, from Rio de Janeiro, Brazil. The association between hepcidin and retinol levels, hematologic parameters, and body mass index (BMI) was analyzed using a generalized linear model with and without adjustment for C-reactive protein (CRP) level.

The lanthipeptide biosynthetic clusters of the domain Archaea.

Research on Archaea's secondary metabolites is still lagging behind that of Bacteria and Eukarya. Our goal was to contribute to this knowledge gap by analyzing the lanthipeptide's clusters in Archaea. As previously proposed, Archaea encodes only class II synthetases (LanMs), which we found to be confined to the class Halobacteria (also known as haloarchaea).

Fatigue, depression, and physical activity in patients with malignant hyperthermia: a cross-sectional observational study.

Background: Malignant Hyperthermia (MH) is a pharmacogenetic disorder triggered by halogenated anesthesia agents/succinylcholine and characterized by hypermetabolism crisis during anesthesia, but also by day-to-day symptoms, such as exercise intolerance, that may alert the health professional.

Objective: The study aimed to analyze the incidence of fatigue in MH susceptible patients and the variables that can impact perception of fatigue, such as the level of routine physical activity and depression.

Methods: A cross-sectional observational study was carried out with three groups .

Effects of a Pediatric Weight Management Intervention on Parental Stress.

Few studies have examined the associations of pediatric weight management interventions (PWMIs) with reduction in parental stress. We sought to examine the extent to which a PWMI reduces parental stress and whether changes in parental healthful feeding practices and support for physical activity are associated with reduction in parental stress. We analyzed data from the Clinic and Community Approaches to Healthy Weight randomized controlled trial (RCT).

Administration of MP101 in an Elderly Nursing Home during the COVID-19 Pandemic: Immunological and Nutritional Impact.

The elderly population living in nursing homes is particularly vulnerable to COVID-19 although individual susceptibility to SARS-CoV-2 infection may be related to the host microbiota. The objective of this work was to investigate the effect of MP101 on the functional (Barthel index), cognitive (GDS/FAST), and nutritional (MNA) status as well as on the nasal and fecal inflammatory profiles of elderly residents living in a nursing home that is highly affected by COVID-19. A total of 25 residents participated in the trial, which involved the daily ingestion of a dairy product ( MP101: 9.

Planned Evaluation of the Healthy Weight Clinic Pediatric Weight Management and Implementation: Massachusetts-CORD 3.0.

Despite evidence that offering multidisciplinary treatment for children with obesity is effective, access to evidence-based pediatric weight management interventions (PWMIs) is limited. The PWMI is a multidisciplinary approach in primary care that improves BMI among children with a BMI ≥ 85th percentile. To describe the method by which we will evaluate the adoption, acceptability, and feasibility of integrating and implementing a multidisciplinary (HWC) into primary care.

Design and Approach of the Healthy Weight Clinic Pediatric Weight Management Intervention Package and Implementation: Massachusetts-CORD 3.0.

Although proven effective interventions for childhood obesity exist, there remains a substantial gap in the adoption of recommended practices by clinicians. The aims are to: (1) package implementation and training supports to facilitate the adoption of the evidence-based Pediatric Weight Management Intervention (PWMI) (based on three previous effectiveness trials); (2) pilot and evaluate the packaged PWMI; and (3) develop a sustainability and dissemination plan. We used the Consolidated Framework of Implementation Research constructs to create an Implementation Research Logic Model that defined the facilitators and barriers of the PWMI.

Chikungunya Virus Exposure Partially Cross-Protects against Mayaro Virus Infection in Mice.

Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are closely related members of the Semliki Forest virus antigenic complex classified as belonging to the genus of the family . These viruses cause human disease, with sudden fever and joint inflammation that can persist for long periods. CHIKV is the causative agent of large outbreaks worldwide, and MAYV infection represents a growing public health concern in Latin America, causing sporadic cases and geographically limited outbreaks.

Evaluation of the food environment of public hospitals in a Brazilian metropolis.

Objective: To characterise the food environment of public hospitals in a Brazilian metropolis.

Design: A cross-sectional study involving the audit of mini-kitchens, non-commercial food services, commercial food services and vending machines within hospitals and interviews with workers and managers. Environmental dimensions assessed included: availability, accessibility, affordability, convenience, nutrition information, promotion and advertising, infrastructure for food and ambience, in addition to decisions-level aspects.

Methodological aspects of the assessment of dietary intake in the Brazilian National Survey on Child Nutrition (ENANI-2019): a population-based household survey.

This manuscript aims to describe the methodological, operational, and quality control aspects of the assessment of dietary intake in children under five years of age participating in the Brazilian National Survey on Child Nutrition (ENANI-2019), a household survey in a probability sample of Brazilian households. Two instruments were developed to assess child feeding practices - a structured, current status-type questionnaire and a 24-hour dietary recall (24HR), both installed in a mobile data collection device used by previously trained interviewers. A Photographic Manual for Quantification of Children's Dietary Intake was specifically developed for and used in the survey as a support aid to identify and quantify foods reported in the 24HR.

Methodological aspects of the micronutrient assessment in the Brazilian National Survey on Child Nutrition (ENANI-2019): a population-based household survey.

This article aims to present methodological aspects on the collection, analyses, coverage, challenges, and the lessons learned from laboratory assessment of micronutrients on the Brazilian National Survey on Child Nutrition (ENANI-2019). This is a household survey on a probability sample of children under five years of age from 123 Brazilian municipalities in all 26 states and the Federal District. Blood samples were drawn by venipuncture at the homes of children 6 to 59 months of age.

General methodological aspects in the Brazilian National Survey on Child Nutrition (ENANI-2019): a population-based household survey.

This article aims to present general methodological aspects of the Brazilian National Survey on Child Nutrition (ENANI-2019), from the conception of the study design to details of the data collection. This is a household-based population survey with a sample calculated at 15,000 households to identify children under five years of age, conducted in 123 municipalities in Brazil's 26 states and the Federal District. ENANI-2019 includes data on breastfeeding and dietary intake; anthropometric nutritional status of all children and their biological mothers; and nutritional status concerning the following micronutrients: iron (hemoglobin and ferritin), zinc, selenium, and vitamins A, B1, B6, B12, D, E, and folic acid of children from 6 to 59 months of age.

Methodological aspects of the anthropometric assessment in the Brazilian National Survey on Child Nutrition (ENANI-2019): a population-based household survey.

The article presents methodological aspects of anthropometric assessment of nutritional status in children under five years of age and their biological mothers. It discusses the strategies used for training and data collection in the Brazilian National Survey on Child Nutrition (ENANI-2019). ENANI-2019 is a population-based household survey conducted in 123 municipalities in Brazil's 26 states and the Federal District.

Sampling plan of the Brazilian National Survey on Child Nutrition (ENANI-2019): a population-based household survey.

The article describes methodological aspects in defining the study population, sampling plan, and sample weigthing and calibration of effective sample of the Brazilian National Survey on Child Nutrition (ENANI-2019). This population-based household survey assessed breastfeeding and dietary intake, anthropometric assessment of nutritional status, and micronutrient deficiencies by blood biomarkers in children under five years of age. The data were obtained with a probability sample, with stratification by the five geographic regions in the country and clustering by census enumeration areas (CEAs).

Are biodegradable plastics an environmental rip off?

While the use of biodegradable polymers is recognized as a global strategy to minimize plastic pollution, the technical standards (TS) used to attest their biodegradability may not be in compliance with most environmental parameters observed aquatic ecosystems. Indeed, through a careful assessment of the TS currently in use, this study evidenced that these guidelines cover only a fraction of the biogeochemical parameters seen in nature and largely disregard those that occur in the deep-sea. Thus, these TS may not be able to ensure the degradation of such polymers in natural environments, where microbial activity, pH, temperature, salinity, UV radiation and pressure are highly variable.

Sepsis expands a CD39 plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity.

Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop persistent immunosuppression with increased risk of recurrent infections.

Evaluation of microaeration strategies in the digestion zone of UASB reactors as an alternative for biogas desulfurization.

This study aimed at evaluating the microaeration as an alternative for hydrogen sulfide removal from biogas of UASB reactors treating sewage. The set-up consisted of two pilot-scale UASB reactors, including a conventional anaerobic and a modified UASB reactor, operated under microaerated conditions. Air was supplied in the digestion zone, at 1 and 3 m from the bottom of the reactor, and three different air flows were investigated: 10, 20, and 30 mL.