Impact of age on premenstrual syndrome prevalence and severity: A population-based survey in Brazil.

Objective: To evaluate the relationship between premenstrual disorders (PMD) and age, we analyzed the prevalence and severity of psycho-emotional and physical symptoms in a representative sample of Brazilian women.

Methods: This observational and retrospective study analyzed data from Brazilian women aged 20-49 years from five regions of the country who reported premenstrual symptoms. Participants completed a premenstrual symptom screening questionnaire and self-reported the presence and severity of their symptoms.

Real-World Study of Adjuvant Biosimilar Trastuzumab-dkst for HER2-Positive Breast Cancer Treatment in a Brazilian Population.

Introduction: Biological monoclonal antibodies play a pivotal role in cancer treatment, with biosimilars significantly enhancing their accessibility. In Brazil's ethnically diverse setting, real-world evidence is crucial for assessing the effectiveness and applicability of these therapies in routine clinical practice.

Methods: We performed a multicentric, observational, prospective real-world study on biosimilar trastuzumab-dkst for adjuvant treatment of early HER2-positive breast cancer in Brazilian patients.

Combination of 5% cysteamine and 4% nicotinamide in melasma: Efficacy, tolerability, and safety.

Background: Melasma is a chronic dermatosis that impacts the patient's quality of life and can present considerable challenges in terms of effective treatment.

Objective: To evaluate the effectiveness, tolerability, and safety of 5% cysteamine combined with 4% nicotinamide in female subjects with melasma.

Methods: This single-center, single-arm, prospective, open-label study evaluated patients with melasma using a combination cream of 5% cysteamine and 4% nicotinamide in a progressive regimen (60 min in the first month, 120 min in the second month, and 180 min in the third month).

Assessment of lifestyle, blood pressure, and cholesterol in pharmaceutical industry professionals.

Introduction: Cardiovascular diseases are the leading cause of death worldwide.

Objectives: To elucidate the lifestyle of in pharmaceutical company professionals, evaluating cardiovascular risk factors.

Methods: This is an observational, longitudinal, and prospective study conducted with 1,875 individuals of both sexes.

Implementation of an organized colorectal cancer screening program through quantitative fecal immunochemical test followed by colonoscopy in an urban low-income community: Guidance and strategies.

Fecal Immunochemical Test (FIT) followed by a colonoscopy is an efficacious strategy to improve the adenoma detection rate and Colorectal Cancer (CRC). There is no organized national screening program for CRC in Brazil. The aim of this research was to describe the implementation of an organized screening program for CRC through FIT followed by colonoscopy, in an urban low-income community of São Paulo city.

Precision technologies for predictive diagnosis and study of the allometric growth of broiler chickens with breast myopathies.

1. An experiment was carried out to validate techniques as predictive diagnostic tools for breast myopathies and to study the allometric growth of distinct parts of the body and meat quality of broilers.2.

Different litter compositions influence broiler chicken locomotion.

Background: Bedding material must absorb moisture, reduce impacts, and allow chicken to express their natural behavior reducing the occurrence of injuries in the footpad and joints, and improving carcass quality and performance.

Aims: This study evaluated different bedding materials with different levels of inclusion of dried grass (Zoysia japonica) on the development of lesions in the locomotor system of broiler chickens.

Methods: One thousand eight-day-old male chicks of the Cobb 500 were distributed in a completely randomized design with a 3 × 2 factorial scheme: three levels of grass inclusion and two bedding materials (100% wood shavings; 100% rice husks; 25% grass and 75% wood shavings; 25% grass and 75% rice husks; 50% grass and 50% wood shavings; 50% grass and 50% rice husks).

Techniques for assessment of myopathies in broiler chicken breasts using a biopsy as a support tool.

An experiment was conducted to validate non-invasive evaluation techniques as evaluation tools for the myopathies wooden breast and white striping that affect broilers, using biopsy as a support tool. It evaluated 30 Cobb 500® broiler chickens in a completely randomized design consisting of two sexes (males and females) and 15 replications per treatment. At 14, 21, 35, 42 and 49 days, the surface temperature of the birds' breasts was recorded using infrared thermography, analysis of fillet depth, and echogenicity by ultrasound imaging.

Biosimilar Use in Breast Cancer Treatment: A National Survey of Brazilian Oncologists' Opinions, Practices, and Concerns.

Purpose: Breast cancer is the most common malignancy in Brazilian women, with 66,280 new cases in 2020 (with 20% overexpressing human epidermal growth factor receptor 2 [HER2]). The trastuzumab biosimilar was the first oncology biosimilar approved in Brazil for HER2-positive breast cancer treatment. This study aimed to assess the current level of knowledge of biosimilars, comfort of use, extrapolation indications, and switching of practices among oncologists in Brazil.

Coverage for the cost of outpatient nursing procedures by the Unified Health System: a percentage analysis.

Objective: To analyze the percentage of the coverage of transfers from the Brazilian Unified Health System regarding nursing procedures conducted in the Outpatient facility of a University Hospital.

Method: Quantitative, exploratory, descriptive case study. The sample for calculating the mean total direct costs was composed of non-participant observations of 656 procedures.

Characterization of different types of broiler bedding including dehydrated grass and their influence on production.

The objective is to evaluate different bedding materials, including dehydrated grass, on performance and carcass yield and verify the physicochemical and microbiological characteristics of materials. The completely randomized experiment comprised 1,080 chicks in a 3 × 2 factorial design with three levels of dehydrated grass (0%, 25%, and 50%) and two bedding materials (rice husks and shavings). Total microorganism count and physicochemical characteristics, surface temperature of birds, and performance of birds were analyzed up to 42 days of age, when birds were slaughtered, and carcass yield was evaluated.

Culture isolation and molecular identification of Blastocystis sp. in Brazilian human isolates: preliminary results.

Blastocystis sp. is a protist commonly found in stool samples of humans and animals. Biological and genetic factors of this organism remain controversial.

Subtypes of sp. isolated in fecal samples from transplant candidates in São Paulo, Brazil.

sp. is an intestinal protozoan commonly found in fecal samples of many animal species, including humans, but poorly studied in transplant candidates. The aim of this study was to evaluate the occurrence and molecular identification of sp.

Screening of Strongyloides infection using an ELISA test in transplant candidates.

Objectives: Hyperinfection or disseminated strongyloidiasis has been frequently reported after transplants and is related to high mortality. This study aimed to screen for strongyloidiasis using serological diagnoses in transplant candidates.

Methods: An ELISA test was performed with filariform larvae of Strongyloides venezuelensis as a source of antigen.

IgG reactivity with 40-35 kDa soluble and membrane antigen of Strongyloides venezuelensis in immunocompromised patients.

Immunocompromised patients constitute a risk group for the development of severe clinical forms of human strongyloidiasis. The diagnosis of this infection is primarily performed by parasitological techniques, but with low sensitivity. Serological techniques appear as an alternative, especially with heterologous antigens use.

Docking simulation between HIV peptidase inhibitors and Trypanosoma cruzi aspartyl peptidase.

Objective: The low investment in research, diagnosis and treatment are factors that contribute to the continuity of Chagas' disease as a neglected tropical diseases (NTDs). In this context, the repositioning of drugs represents a useful strategy, in the search for new chemotherapeutic approaches for NTDs. HIV aspartic peptidase inhibitors (HIV IPs) are good candidates for drug repurposing.

OCCASIONAL DIGESTIVE HEMORRHAGE IN CHILDREN DUE TO STRONGYLOIDIASIS: IMPORTANCE OF PARASITOLOGIC TESTING.

Objective: To describe an uncommon case of infection by Strongyloides stercoralis (S. stercoralis) in a 4-month-old child and to highlight the importance of early diagnosis.

Case Description: The patient was a male child from the city of Videira, State of Santa Catarina, Southern Brazil, who was born preterm by Cesarean-section, weighing 1,655 g, and stayed in the neonatal intensive care unit for 20 days.

Molecular diagnosis of Strongyloides stercoralis among transplant candidates.

Strongyloidiasis can occur without any symptoms or as a potentially fatal hyperinfection or disseminated infection, principally in immunosuppressed patients. Our study aimed to evaluate the application of conventional polymerase chain reaction (cPCR) and real-time PCR (qPCR). Polymerase chain reaction (PCR) and real-time PCR (qPCR) targeting the 18S rRNA gene for detection of Strongyloides stercoralis infection among transplant candidates were applied in stool samples obtained from 150 transplant candidates, preliminarily analyzed by parasitological methods.

The cost of transcatheter aortic valve implantation according to different access routes.

Objective: Identifying the average direct cost of TAVI (Transcatheter Aortic Valve Implantation) for the different access routes.

Method: This is a research with a quantitative, exploratory and descriptive approach carried out in a government teaching hospital in the state of São Paulo.

Results: The average direct cost of TAVI procedures by the access routes resulted in R$82,826.

Coronary Artery Bypass Graft Surgery Cost Coverage by the Brazilian Unified Health System (SUS).

Introduction: Cost management has been identified as an essential tool for the general control and evaluation of health organizations.

Objectives: To identify the coverage percentage of transferred funds from the Unified Health System for coronary artery bypass grafts in a philanthropic hospital having a consolidated costing system in the municipality of São Paulo.

Methods: A quantitative, descriptive and cross-sectional research with information provided from a database composed of 1913 patients undergoing coronary artery bypass graft from March 13 to September 30, 2012, including isolated elective coronary artery bypass graft with the use of extracorporeal circulation.

Potential immunological markers for diagnosis of human strongyloidiasis using heterologous antigens.

Strongyloides venezuelensis is a parasitic nematode of rodents that is frequently used to obtain heterologous antigens for immunological diagnosis of human strongyloidiasis. The aim of this study was to identify antigens from filariform larvae of S. venezuelensis for immunodiagnosis of human strongyloidiasis.

Financial impact of nursing professionals staff required in an Intensive Care Unit.

Objective: to calculate the cost of the average time of nursing care spent and required by patients in the Intensive Care Unit (ICU) and the financial expense for the right dimension of staff of nursing professionals.

Method: a descriptive, quantitative research, using the case study method, developed in adult ICU patients. We used the workload index - Nursing Activities Score; the average care time spent and required and the amount of professionals required were calculated using equations and from these data, and from the salary composition of professionals and contractual monthly time values, calculated the cost of direct labor of nursing.