Publications by authors named "Castelo M"
Article Synopsis
- The study examines the impact of illicit substance use during pregnancy, noting a 4-fold increase over two decades and its negative effects on mothers and fetuses.
- A multicenter retrospective analysis from 2016 to 2021 included 852 pregnant trauma patients (PTPs), with 9.8% testing positive for substances, primarily THC and methamphetamine.
- Findings showed that PTPs with positive urine toxicology had higher rates of blunt head injuries, extremity injuries, domestic violence incidents, and uterine contractions, but similar maternal complication rates compared to those who tested negative.
Article Synopsis
- * The study involved 37 FPLD patients and 74 healthy controls, analyzing various parameters such as thigh skinfold thickness and leg fat percentage, alongside genetic testing to classify patients into two groups: FPLD+ and FPLD1.
- * Results indicated a significant statistical difference in key diagnostic parameters between FPLD groups, revealing a new cutoff point of 20 mm for thigh skinfold thickness in women and suggesting that a leg fat percentage below 29.6% could assist in FPL
Barometric pressure is an environmental factor involved in the modulation of a variety of activities in insects. Generally, a drop in barometric pressure precedes the arrival of weather conditions that can affect insect activities and life expectancy. We simulated different scenarios of pressure drop in a modified hermetic chamber and studied their influence on the host-seeking behaviour of the larvae of the robber fly Mallophora ruficauda using air stationary olfactometers.
View Article and Find Full Text PDFPinniped respiratory mites of the species have been recorded from various locations around the world but not from continental Argentina. In the present work, we document for the first time the presence of on on the Argentine mainland. A total of 23 adult and 381 immature mites were collected from the nose and nasopharyngeal cavity during a necropsy.
View Article and Find Full Text PDFParkin R274W mutation affects muscle and mitochondrial physiology.
Biochim Biophys Acta Mol Basis Dis
October 2024
Recessive mutations in the Parkin gene (PRKN) are the most common cause of young-onset inherited parkinsonism. Parkin is a multifunctional E3 ubiquitin ligase that plays a variety of roles in the cell including the degradation of proteins and the maintenance of mitochondrial homeostasis, integrity, and biogenesis. In 2001, the R275W mutation in the PRKN gene was identified in two unrelated families with a multigenerational history of postural tremor, dystonia and parkinsonism.
View Article and Find Full Text PDFArticle Synopsis
- Almost 10% of pregnant women experience serious injuries, but how serious injuries affect them and their babies isn’t well understood.
- A study looked at 950 pregnant women with injuries and found that about 3.4% had severe injuries, which led to more complications and higher risks for both the mother and baby.
- Severely injured women had more surgeries and a higher chance of losing their baby, so doctors need to be very careful when taking care of them.
PRE1BRAZIL Protocol: A Randomized Controlled Trial to Evaluate the Effectiveness and Safety of the DPP-4 Inhibitor Alogliptin in Delaying the Progression of Stage 2 Type 1 Diabetes.
Diabetes Metab Syndr Obes
February 2024
Background: The incidence of Type 1 Diabetes Mellitus (T1DM) is on the rise. Since there is no curative treatment, it is urgent to look for therapies that can delay disease progression and protect pancreatic β-cells. Dipeptidyl peptidase-4 inhibitors (DPP-4i) have shown potential in modulating inflammation and preventing β-cell destruction.
View Article and Find Full Text PDFArticle Synopsis
- Doctors often use CT scans to check for injuries after car accidents, but for pregnant women, these scans can be risky for the baby.
- A study looked at how often pregnant women involved in car crashes got CT scans at 12 different hospitals from 2016 to 2021.
- The results showed a big difference in the number of scans given at each hospital, suggesting there should be clearer rules to keep both moms and babies safe while still finding any injuries.
Background: The global benchmark cut-offs were set for laparoscopic liver resection procedures: left lateral sectionectomy, left hepatectomy, and right hepatectomy. We aimed to compare the performance of our North American center with the established global benchmarks.
Methods: This is a single-center study of adults who underwent laparoscopic liver resection between 2010 to 2022 at the Toronto General Hospital.
Background: The role of endovascular interventions (EI) for blunt carotid and vertebral artery injuries (BCI and BVI) is poorly defined. The purpose of this study was to assess the efficacy of EI compared with antithrombotic therapy (AT) to inform future prospective study.
Methods: Retrospective review (2017-2022) of records at a Level I trauma center to determine injury, treatment, and outcome information.
Predictors of fetal delivery in pregnant trauma patients: A multicenter study.
J Trauma Acute Care Surg
January 2024
Background: Pregnant trauma patients (PTPs) undergo observation and fetal monitoring following trauma due to possible fetal delivery (FD) or adverse outcome. There is a paucity of data on PTP outcomes, especially related to risk factors for FD. We aimed to identify predictors of posttraumatic FD in potentially viable pregnancies.
View Article and Find Full Text PDFImportance: Colorectal cancer (CRC) is uncommon in adults younger than 50 years of age, so this population may experience delays to treatment that contribute to advanced stage and poor survival.
Objective: To investigate whether there is an association between time from presentation to treatment and survival in younger adults with CRC.
Design, Setting, And Participants: This retrospective cohort study used linked population-based data in Ontario, Canada.
Article Synopsis
- The study looked at the effects of pregnancy in older moms (35 years and older) who had trauma and compared them to younger pregnant moms.
- It found that older moms had more injuries to certain organs like the pancreas and stomach, but there was no difference in the chance of delivering the baby after trauma.
- Because of this, they decided that older moms don’t need extra monitoring compared to younger moms after a trauma.
Purpose: We examined the impact of non-adherence to adjuvant endocrine therapy (ET) on the risk and site of recurrence among older women with early stage, hormone receptor positive (HR+) breast cancer (EBC).
Methods: A population-based cohort of women age ≥ 65 years with T1N0 HR + EBC who were diagnosed between 2010 and 2016 and treated with breast-conserving surgery (BCS) + ET was identified. Treatment and outcomes were ascertained through linkage with administrative databases.
Objective: In response to COVID-19, the fall prevention program (FPP) at Sunnybrook Health Sciences Centre was modified to be delivered virtually. We compared patient populations assessed for the FPP virtually versus in-person to explore equitable accessibility.
Methods: A retrospective chart review was performed.
Background And Aims: Non-pharmacological interventions to improve patient-reported outcomes of colonoscopy may be effective at mitigating negative experiences and perceptions of the procedure, but research to characterise the extent and features of studies of these interventions is limited.
Methods: We conducted a scoping review searching multiple databases for peer-reviewed publications of randomised controlled trials conducted in adults investigating a non-pharmacological intervention to improve patient-reported outcomes of colonoscopy. Study characteristics were tabulated and summarised narratively and graphically.
Introduction: The single most important predictor of pancreas-specific complications (PSCs) after pancreatic trauma is injury to the main pancreatic duct (MPD). Pancreatography has been recommended to evaluate the integrity of the MPD. In addition, pancreatic duct stents have been proposed to prevent or treat PSC.
View Article and Find Full Text PDFBackground: Choosing Wisely guidelines recommend against surgical axillary staging (AS) in women ≥70 years with ER+/HER2- early stage breast cancer (BC). This study examined the impact of AS omission on survival in older patients with BC.
Methods: This was a population-based cohort study using health administrative data in Ontario, Canada.
Background & Aims: Younger adults (aged <50 years) with colorectal cancer (CRC) may have prolonged delays to diagnosis and treatment that are associated with adverse outcomes. We compared delay intervals by age for patients with CRC in a large population.
Methods: This was a population-based study of adults diagnosed with CRC in Ontario, Canada, from 2003 to 2018.
Background: The role of viral hepatitis status in post-hepatectomy outcomes has yet to be delineated. This large, multicentred contemporary study aimed to evaluate the effect of viral hepatitis status on 30-day post-hepatectomy complications in patients treated for hepatocellular carcinoma (HCC).
Methods: Patients from the National Surgical Quality Improvement Program (NSQIP) database with known viral hepatitis status, who underwent hepatectomy for HCC between 2014 and 2018, were included.
Outcome disparities between adults <50 with colorectal cancer (CRC) and older adults may be explained by clinical delays. This study synthesized the literature comparing delays and outcomes between younger and older adults with CRC. Databases were searched until December 2021.
View Article and Find Full Text PDFBackground: Clinical delays may be important contributors to outcomes among younger adults (<50 years) with colorectal cancer (CRC). We aimed to describe delay intervals for younger adults with CRC using health administrative data to understand drivers of delay in this population.
Methods: This was a population-based study of adults <50 diagnosed with CRC in Ontario, Canada from 2003 to 2018.