Synthesis and properties of benzo [d,e]estra-1,3,5(10)-triene-3, 17 beta-diol 17-acetate.

A new pentacyclic analogue of estradiol, benzo[d,e]estradiol 17-acetate, has been prepared and investigated for its hormonal and antitumor activity. Unlike related testosterone derivatives, the new compound did not display any interesting property.

[Varices of the external saphenous vein].

The author indicates the importance in varicose veins of involvement of the external saphenous, making clear the distinction between sapheno-popliteal ostial insufficiency without varices and venous insufficiency with varices. He recommends a surgical approach determined on the basis of good clinical examination and appropriate supplementary examinations: such surgery should always be followed by sclerotherapy.

Infections and anastomotic false aneurysms in reconstructive vascular surgery.

The authors report their experiences in two kinds of late complications of direct reconstructive surgery: infections and anastomotic false aneurysms. Such complications occurred after operations calling for the use of alloplastic prostheses, with an incidence of 2.8% out of all other operations in which prosthesic grafts have been used.