Use of multispecies (Nannochloropsis oceanica, Artemia franciscana, and Arbacia nigra) approach to assess the quality of marine water from Callao Bay, Peru.

Multi-species tests in bioassays offer a holistic view of the ecosystem's response to toxicity, as different species display varying sensitivities to pollutants. This research aimed to assess the ability of toxicity tests' to distinguish contamination levels, examine site-specific effects, and investigate seasonal variability. Using a multispecies approach (Nannochloropsis oceanica, Artemia franciscana, and Arbacia nigra), bioassays evaluated marine water quality from Callao Bay in Peru across four sampling areas (Naval School: PA1, Peruvian Marine Institute: PA2, Callao Pier: PA3, and San Lorenzo Island: PA4).

COVID-19 Vaccination Acceptance and Hesitancy in Healthcare Workers and the General Population: A Systematic Review and Policy Recommendations.

Introduction: The COVID-19 pandemic challenged the scientific community to find and develop a vaccine to fight the disease. However, problems with achieving high vaccine coverage have emerged, even among high-risk groups such as healthcare workers (HCWs).

Objective: The objective of this study is to examine factors that influence HCW's and the general population's adherence to COVID-19 vaccination and national policies to vaccinate HCWs and other target groups.

The 22q11.2 Deletion Syndrome from A Biopsychosocial Perspective: A Series of Cases with an ICF-Based Approach.

Unlabelled: The 22q11.2 deletion syndrome (DS) can have a significant impact on functionality. The purpose was to describe 22q11.

Concurrent arsenic, fluoride, and hydrated silica removal from deep well water by electrocoagulation: Comparison of sacrificial anodes (Al, Fe, and Al-Fe).

Some studies have reported the removal of As (As) and fluoride (F) using different sacrificial anodes; however, they have been tested with a synthetic solution in a batch system without hydrated silica (SiO) interaction. Due to the above, concurrent removal of As, F, and SiO from natural deep well water was evaluated (initial concentration: 35.5 μg L As, 1.

Caustics and wavefronts produced by multiple refraction-reflections through plane-parallel plates.

We study the formation of caustics and wavefronts produced by multiple refraction-reflections through a plane-parallel transparent plate, assuming a point source placed at an arbitrary position along the optical axis. The caustic surfaces are obtained by using the envelope's method. Subsequently, the wavefronts are directly related to the involutes, which are associated with the envelopes for all the rays.

Evaluation of limited-sampling strategies to calculate AUC and the role of in Chilean pediatric kidney recipients using extended-release tacrolimus.

Kidney transplantation (KTx) requires immunosuppressive drugs such as Tacrolimus (TAC) which is mainly metabolized by CYP3A5. TAC is routinely monitored by trough levels (C) although it has not shown to be a reliable marker. The area-under-curve (AUC) is a more realistic measure of drug exposure, but sampling is challenging in pediatric patients.

Evolutionary responses of energy metabolism, development, and reproduction to artificial selection for increasing heat tolerance in Drosophila subobscura.

Adaptation to warming conditions involves increased heat tolerance and metabolic changes to reduce maintenance costs and maximize biological functions close to fitness. Evidence shows that energy metabolism evolves in response to warming conditions, but we know little about how heat stress intensity determines the evolutionary responses of metabolism and life history traits. Here, we evaluated the evolutionary responses of energy metabolism and life-history traits to artificial selection for increasing heat tolerance in Drosophila subobscura, using 2 protocols to measure and select heat tolerance: slow and fast ramping protocols.

Rates of instrumental vaginal birth and cesarean and quality of maternal and newborn health care in private versus public facilities: Results of the IMAgiNE EURO study in 16 countries.

Objective: To explore the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic by facility type among 16 European countries, comparing rates of instrumental vaginal birth and cesarean.

Methods: Women who gave birth in the WHO European Region from March 1, 2020, to February 7, 2022, answered a validated online questionnaire. Rates of instrumental birth, instrumental vaginal birth, and cesarean, and a QMNC index were calculated for births in public versus private facilities.

What do we want to know about MOOCs? Results from a machine learning approach to a systematic literature mapping review.

By the end of 2020, over 16,300 Massive Open Online Courses (MOOCs) from 950 universities worldwide had enrolled over 180 million students. Interest in MOOCs has been matched by significant research on the topic, including a considerable number of reviews. This study uses Machine Learning techniques and human expert supervision to generate a comprehensive systematic literature mapping review that overcomes some limitations of the traditional ones and provides a broader overview of the content and main topics studied in the specialized literature devoted to MOOCs.

MOOCs as a massive learning resource for a Higher Education Community. The Universitat Politècnica de València experience using the EdX remote access program.

During the 2020 COVID-19 lockdown, edX launched an initiative, called the Remote Access Program, to give access to free certificates for its Massive Open Online Courses (MOOCs) to the communities of its partners. This paper describes the experience of a Higher Education (HE) institution in Europe participating in this initiative as a strategic action to spread MOOCs, not just as a resource to open the university educational offer but also to improve the professional development possibilities of its community. This case study explores general data about the participation of over 7,700 people (23,4% of the Universitat Politècnica de Valencia's community) in these courses and data from participants (1,515) about their initiative perceptions.

Characterization of personal injuries in the stomatognathic system assessed at the Instituto Nacional de Medina Legal y Ciencias Forenses- Regional Suroccidente between 2015 and 2020.

Introduction: Personal injury forensic reports diagnose and define the damage to the body and health of a person including the stomatognathic system by injuries produced as the consequence of other people’s actions. Objective: To characterize the personal injuries affecting the stomatognathic system as a result of violent actions in 266 cases evaluated at the Instituto Nacional de Medina legal y Ciencias Forenses-Regional Suroccidente (Cali, Colombia) between 2015 and 2020. Materials and methods: We conducted a descriptive cross-sectional study to characterize the personal injuries affecting the stomatognathic system.

Approach for designing thick cemented doublet lenses based on the caustic surface.

A new, to the best of our knowledge, method for designing a thick-lens achromatic doublet based on the concept of a caustic surface to correct both third- and fifth-order spherical aberration is presented. We consider two different wavelengths brought into coincidence at the back focal length instead of the effective focal length as it is usually done, to calculate the radii of curvature assuming predefined values for axial thicknesses and their indices of refraction for both lenses. Alternatively, we apply Taylor's series around the optical axis, and to vanish the approximate caustic surface, we obtain the values for the conic constants, which reduce at third- and fifth-order spherical aberration.

Tomato CRABS CLAW paralogues interact with chromatin remodelling factors to mediate carpel development and floral determinacy.

CRABS CLAW (CRC) orthologues play a crucial role in floral meristem (FM) determinacy and gynoecium formation across angiosperms, the key developmental processes for ensuring successful plant reproduction and crop production. However, the mechanisms behind CRC mediated FM termination are far from fully understood. Here, we addressed the functional characterization of tomato (Solanum lycopersicum) paralogous CRC genes.

Symptom cluster analysis of long COVID-19 in patients discharged from the Temporary COVID-19 Hospital in Mexico City.

Introduction: Several reports have emerged describing the long-term consequences of COVID-19 and its effects on multiple systems.

Methods: As further research is needed, we conducted a longitudinal observational study to report the prevalence and associated risk factors of the long-term health consequences of COVID-19 by symptom clusters in patients discharged from the Temporary COVID-19 Hospital (TCH) in Mexico City. Self-reported clinical symptom data were collected telephone calls over 90 days post-discharge.

Development of an efficient marker-free soybean transformation method using the novel bacterium Ochrobactrum haywardense H1.

We have discovered a novel bacterium, Ochrobactrum haywardense H1 (Oh H1), which is capable of efficient plant transformation. Ochrobactrum is a new host for Agrobacterium-derived vir and T-DNA-mediated transformation. Oh H1 is a unique, non-phytopathogenic species, categorized as a BSL-1 organism.

Quality of facility-based maternal and newborn care around the time of childbirth during the COVID-19 pandemic: online survey investigating maternal perspectives in 12 countries of the WHO European Region.

Background: Multi-country studies assessing the quality of maternal and newborn care (QMNC) during the COVID-19 pandemic, as defined by WHO Standards, are lacking.

Methods: Women who gave birth in 12 countries of the WHO European Region from March 1, 2020 - March 15, 2021 answered an online questionnaire, including 40 WHO Standard-based Quality Measures.

Findings: 21,027 mothers were included in the analysis.

Effect of , , and Genetic Polymorphisms in Immunosuppressive Treatment in Chilean Kidney Transplanted Patients.

Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms in genes related to the metabolism and transport of these drugs, namely , , and genes, has been evaluated in diverse populations. However, the impact of these polymorphisms on drug disposition is not well established in Latin American populations.

Construction and validation of a logical model for specialized Rehabilitation Centers.

Objective: To build and validate a logical model for health care in Specialized Rehabilitation Centers (CER) by analyzing the work process and organizational issues of centers in Rio Grande do Norte.

Methods: This is a methodological study developed in three stages: 1) documentary research of legislation and ordinances concerning the healthcare service and the Disability Care Network (RCPD); 2) focus groups with a Census study of the CER in Rio Grande do Norte to understand and assess the daily activities of the service; and 3) systematization of the information collected and, finally, proposition and validation of the evaluative logical model.

Results: The model encompassed five central categories of the work and organizational process: "demands", "resources" (inputs, financial and workforce), "processes", "products and results" and "mission, values and external factors".

Association of Fluid Balance and Survival of Pediatric Patients Treated With Extracorporeal Membrane Oxygenation.

The effect of positive fluid balance (FB) on extracorporeal membrane oxygenation (ECMO) outcomes in pediatric patients remains unknown. We sought to evaluate if positive FB in pediatric intensive care unit (PICU) patients with respiratory and/or cardiac failure necessitating ECMO was associated with increased morbidity or mortality. This was a multicenter retrospective cohort study of data from the deidentified PEDiatric ECMO Outcomes Registry (PEDECOR).

High-flow nasal cannula therapy for hypoxemic respiratory failure in patients with COVID-19.

Introduction: High-flow nasal cannula (HFNC) therapy in patients with hypoxemic respiratory failure due to COVID-19 is poorly understood and remains controversial.

Methods: We evaluated a large cohort of patients with COVID-19-related hypoxemic respiratory failure at the temporary COVID-19 hospital in Mexico City. The primary outcome was the success rate of HFNC to prevent the progression to invasive mechanical ventilation (IMV).

Impact of preemptive hospitalization on health outcomes at the temporary COVID-19 hospital in Mexico City: a prospective observational study.

Introduction: In response to the evolution of the coronavirus disease 2019 (COVID-19) pandemic, the admission protocol for the temporary COVID-19 hospital in Mexico City has been updated to hospitalize patients preemptively with an oxygen saturation (SpO) of >90%.

Methods: This prospective, observational, single-center study compared the progression and outcomes of patients who were preemptively hospitalized those who were hospitalized based on an SpO ⩽90%. We recorded patient demographics, clinical characteristics, COVID-19 symptoms, and oxygen requirement at admission.

Gut Microbiota of Contributes to Its Heat Tolerance and Is Sensitive to Transient Thermal Stress.

The gut microbiota can contribute to host physiology leading to an increase of resistance to abiotic stress conditions. For instance, temperature has profound effects on ectotherms, and the role of the gut microbiota on the thermal tolerance of ectotherms is a matter of recent research. However, most of these studies have been focused on single static temperatures instead of evaluating thermal tolerance in a wide range of stressful temperatures.

CYP3A5 and UGT1A9 Polymorphisms Influence Immunosuppressive Therapy in Pediatric Kidney Transplant Recipients.

Tacrolimus (TAC) and mycophenolic acid (MPA) are the main immunosuppressive drugs used in pediatric kidney transplantation. Single nucleotide polymorphisms (SNPs) in metabolizing enzymes and transporters might influence plasma levels of these drugs. Herein, we sought to determine the influence of SNPs on , and genes in Chilean pediatric kidney recipients using TAC and MPA.

MnO₂ Nanoparticles Anchored Multi Walled Carbon Nanotubes as Potential Anode Materials for Lithium Ion Batteries.

Herein, we report a facile hydrothermal synthesis of MnO₂ nanoparticles anchored multi walled carbon nanotubes (MnO₂@MWCNTs) as potential anode materials for lithium-ion (Li-ion) batteries. The prepared MnO₂@MWCNTs were characterized by several techniques which confirmed the formation of MnO₂ nanoparticles anchored MWCNTs. The X-ray diffraction and Raman-scattering analyses of the prepared material further revealed the effective synthesis of MnO₂@MWCNTs.

Experimental evolution on heat tolerance and thermal performance curves under contrasting thermal selection in Drosophila subobscura.

Ectotherms can respond to global warming via evolutionary change of their upper thermal limits (CT ). Thus, the estimation of CT and its evolutionary potential is crucial to determine their vulnerability to global warming. However, CT estimations depend on the thermal stress intensity, and it is not completely clear whether its evolutionary capacity can be affected.