Publications by authors named "Cassie Yang"

Sulfur-derived functional groups represent prevalent motifs in highly sought-after small molecules, such as active pharmaceutical ingredients (APIs). Thioethers are one such example, being commonly encountered in APIs, prodrugs, and as valuable synthetic "linchpins" to access an array of sulfur-derived functional groups. While nucleophilic aromatic substitution (SAr) has traditionally been used to synthesize aryl thioethers, modern approaches leverage transition metals to catalyze thermal or photochemical cross-coupling.

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  • Skin adhesive tapes (SATs) are widely used for wound closure in procedures like vertebral body stenting (VBS), which has a higher risk of complications due to larger incisions compared to percutaneous vertebroplasty (PVP).
  • In a study of 36 patients who underwent VBS, 91.6% had their wounds closed with SATs, showing high success with minimal complications; only three patients required conventional suture closure.
  • Follow-up at six weeks revealed that all SAT closures healed completely with no significant cosmetic issues or major postoperative complications.
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  • Multiple spinal epidural abscesses and systemic infections can lead to severe complications like sepsis and organ failure, necessitating complex surgical interventions.
  • A 69-year-old woman with multiple abscesses underwent pre-operative resuscitation and targeted surgery, resulting in her recovery without neurological deficits.
  • Successful management of such serious infections relies on a multidisciplinary team to coordinate care and prioritize less invasive surgical options for the patient's safety.
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Aims: To establish cut-off values for Patient-Acceptable Symptom States (PASS) in three Patient Reported Outcome Measures (PROMs), the Constant-Murley Score (CMS) and University of California Los Angeles (UCLA) Shoulder Score and Oxford Shoulder Score (OSS) at 3, 6, and 12-months following reverse shoulder arthroplasty (RSA).

Methods: A retrospective study was conducted for individuals who were treated for massive rotator cuff tear, rotator cuff arthropathy or proximal humerus fractures with RSA from January 2011 and February 2020. This study included patients who have completed the patient reported outcome measures (PROMs) and satisfaction questions preoperatively, and at 3, 6 and 12-months after the procedure.

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Externally calibrated quantitative nuclear magnetic resonance (NMR) approaches offer practical means to simultaneously evaluate chemical identity and content without the addition of calibrants to the test sample. Despite continuous advances in external calibration over the last few decades, adoption of these approaches has been slower than expected. Variations in NMR tube geometry are a commonly overlooked factor that can have a substantial effect on externally calibrated quantitation methods.

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The advent of benchtop nuclear magnetic resonance (NMR) instrumentation has paved the way for the use of this technology away from traditional NMR facility settings. Still, a wider adoption of benchtop NMR systems for routine identification testing has been hampered by inherent instrumental limitations (including low sensitivity and reduced signal dispersion) and workflow automation challenges. The present study summarizes the results of a cross-company collaboration aiming at the development of rapid, automated identification tests for incoming materials in liquid form intended for pharmaceutical manufacturing.

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