Genetic Suppression of Basement Membrane Defects in by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.

Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxidasins are extracellular peroxidases implicated in the unique sulfilimine cross-links between type IV basement membrane collagens. Loss of function in the peroxidasin PXN-2 results in fully penetrant embryonic or larval lethality.