Publications by authors named "Cassiana Sousa"

Article Synopsis
  • The study investigated the effects of a lactococci strain that either produced or delivered the precursor to the antimicrobial peptide LL37 (hCAP18) in alleviating chemically induced colitis in mice.
  • Mice treated with LL-Probi-H1:hCAP18 experienced reduced colitis severity, with increased immune markers IL17A and IL10 observed in their lymph nodes.
  • Although L. lactis altered gut microbiota composition, a fecal transplant from treated mice did not improve colitis symptoms in new recipients.
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is a gram positive facultative anaerobe widely used in the dairy industry and human health. subsp. NCDO 2118 is a strain that exhibits anti-inflammatory and immunomodulatory properties.

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Lactococcus lactis is a bacteria with high biotechnological potential, where is frequently used in the amino acid production and production of fermented dairy products, as well as drug delivery systems and mucosal vaccine vector. The knowledge of a functional core proteome is important extremely for both fundamental understanding of cell functions and for synthetic biology applications. In this study, we characterized the L.

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Background: Corynebacterium pseudotuberculosis is classified into two biovars, nitrate-negative biovar Ovis which is the etiologic agent of caseous lymphadenitis in small ruminants and nitrate-positive biovar Equi, which causes abscesses and ulcerative lymphangitis in equines. The aim of this study was to develop a quadruplex PCR assay that would allow simultaneous detection and biovar-typing of C. pseudotuberculosis.

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Based on the ability of nitrate reductase synthesis, is classified into two biovars: Ovis and Equi. Due to the presence of nitrate reductase, the Equi biovar can survive in absence of oxygen. On the other hand, Ovis biovar that does not have nitrate reductase is able to adapt to various ecological niches and can grow on certain carbon sources.

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and its supernatant showed protective effects in different chemically-induced colitis models in mice. Recently, we described 7 peptides found in the supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM). These peptides were able to inhibit NF-κB pathway and showed anti-inflammatory properties in a DiNitroBenzene Sulfate (DNBS)-induced colitis model.

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