Calibrated Breast Density Measurements.

Rationale And Objectives: Mammographic density is an important risk factor for breast cancer, but translation to the clinic requires assurance that prior work based on mammography is applicable to current technologies. The purpose of this work is to evaluate whether a calibration methodology developed previously produces breast density metrics predictive of breast cancer risk when applied to a case-control study.

Materials And Methods: A matched case control study (n = 319 pairs) was used to evaluate two calibrated measures of breast density.

Generalized breast density metrics.

Mammograms represent data that can inform future risk of breast cancer. Data from two case-control study populations were analyzed. Population 1 included women (N  =  180 age matched case-control pairs) with mammograms acquired with one indirect x-ray conversion mammography unit.