The effect of ketamine-assisted group therapy on treatment-resistant mental health conditions in firefighters: a prospective observational case series.

Objective: Firefighters display elevated risk for diagnoses of mental health illnesses. Psychedelic-assisted therapies show promise in the treatment of clinically challenging conditions. This observational case series analyzed data from firefighters with mental health diagnoses who participated in a 12-week ketamine-assisted group therapy treatment plan.

Regional variations in cingulate cortex glutamate levels: a magnetic resonance spectroscopy study at 3 T.

Regional variations in glutamate levels across the cingulate cortex, decreasing rostral to caudal, have been observed previously in healthy volunteers with proton magnetic resonance spectroscopy (H-MRS) at 7 T. This study sought to explore cingulate cortex glutamate trends further by investigating whether a similar gradient could be detected at 3 T, the effect of sex, as well as whether individual variations gave rise to more than one regional glutamate pattern. H-MRS at 3 T [Phillips Elition; semi-localization by adiabatic selective refocusing, echo time (TE)/repetition time (TR) = 32/5,000] was acquired in four cingulate regions: the anterior, midanterior, midposterior, and posterior cortices, in 50 healthy participants (26 F) scanned at a fixed time of day and with controlled food intake.

A systematic review and meta-analysis of synthetic cathinone use and psychosis.

Rationale: Synthetic cathinones (SC), commonly referred to as "bath salts", are stimulants resembling the natural alkaloid cathinone found in the khat plant. These substances have the potential to induce serious health risks such as hallucinations, delusions, paranoia and agitation which can lead to substance-induced psychotic disorders. Despite growing concerns, there is a limited understanding of the association between SC consumption and the devolvement of such psychopathologies.

Pain-related gamma band activity is dependent on the features of nociceptive stimuli: a comparison of laser and contact heat.

Painful contact heat and laser stimulation offer an avenue to characterize nociceptive pathways involved in acute pain processing, by way of evoked potentials. Direct comparisons of radiant laser and contact heat are limited, particularly in context of examining time-frequency responses to stimulation. This is important in light of recent evidence to suggest that gamma band oscillations (GBOs) represent a functionally heterogeneous measure of pain.

Efficacy of topical cannabinoids in the management of pain: a systematic review and meta-analysis of animal studies.

Background/importance: Cannabinoids are emerging as an alternative pain management option, preliminarily supported by preclinical and clinical studies. Unwanted side effects from oral or inhaled cannabinoids remain, however, a major barrier to widespread use. Peripherally acting cannabinoids (eg, topically applied) may circumvent these side effects while providing localized pain management.