KIT Mutation in Gastric Gastrointestinal Stromal Tumor in a Patient With Familial Paraganglioma Syndrome Type 4.

Objective: Familial paraganglioma syndrome type 4 is associated with mutations in the succinate dehydrogenase complex subunit B (SDHB) gene. We report the case of a patient with familial paraganglioma syndrome type 4 with the mutation c.600G>T; p.

LONG TERM FOLLOW-UP OF ONE OF THE FIRST PATIENTS TO RECEIVE HUMAN GROWTH HORMONE THERAPY.

Objective: Treatment of growth hormone (GH) deficiency with GH extracts from human pituitary glands was introduced by Dr. Maurice Raben at Tufts New England Medical Center in 1956. We report long term follow-up of one of the first patients treated with GH.

Geminate consonant grapheme-colour synaesthesia (ideaesthesia).

Background: Synaesthesia is a neurological condition which manifests clinically as an involuntary experience of a sensory or cognitive pathway upon stimulation of a second unrelated sensory or cognitive pathway

Case Presentation: We report a 55 year old male who presented with a life-long history of grapheme-colour synaesthesia in which the triggering grapheme was the double letter 'll' (a geminate consonant), but not 'l' as a single letter. This patient's synaesthesia was also font specific (becoming more evident with serif fonts) and influenced by migraine headache (being suppressed during the prodrome and aura of a migraine headache)

Conclusion: These results suggest that geminate consonants are uniquely processed rather than treated as two individual consonants. Also, the existence of a mechanistic relationship between synesthetic and migrainous events sequence was verified.

Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen.

To generate the first series of prodigiosene conjugates, the tripyrrolic skeleton was appended to estrone, tamoxifen and porphyrin frameworks by way of ester linkers and various hydrocarbon chain lengths. The ability of the conjugates to inhibit various types of cancer cells was evaluated in vitro. The porphyrin conjugates did not exhibit significant activity.