Publications by authors named "Cassandra Baker"

Introduction: Magnetic resonance imaging (MRI) is a rapidly evolving modality, generally considered safe due to lack of ionising radiation. While MRI technology and techniques are improving, many of the safety concerns remain the same as when first established. Patient thermal injuries are the most frequently reported adverse event, accounting for 59% of MRI incidents to the Food and Drug Administration (FDA).

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Article Synopsis
  • The development of histone deacetylase inhibitors (HDACi) for therapy faces challenges like poor solubility and tissue penetration, but nanoparticle encapsulation offers a potential solution.
  • A novel library of β-cyclodextrin-poly (β-amino ester) networks (CDN) was formulated, achieving high loading and slow drug release for HDACi like panobinostat, with a focus on the importance of network architecture.
  • These optimized CDNs showed effective uptake by cancer cells and improved delivery in vivo, leading to reduced tumor growth and confirming the therapeutic benefits of enhanced drug exposure in targeted tissues.
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Ketamine is being prescribed with greater frequency due to an emphasis on multimodal analgesia. With increasing use, uncommon adverse effects associated with ketamine are likely to surface. Limited reports of transient central diabetes insipidus (DI) occurring early after initiation (ie, within 10 hours) of ketamine have been reported.

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The female brain appears selectively vulnerable to the neurotoxic effects of alcohol, but the reasons for this are unclear. One possibility is an exaggerated neuroimmune response in the female brain, such that alcohol increases microglia number and reactivity to subsequent stimuli, such as exercise. It is important to better characterize the interactive neural effects of alcohol and exercise, as exercise is increasingly being used in the treatment of alcohol use disorders.

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Recently, zebrafish have been used to examine hyperglycemia-induced complications (retinopathy and neuropathy), as would occur in individuals with diabetes. Current models to induce hyperglycemia in zebrafish include glucose immersion and streptozotocin injections. Both are effective, although neither is reported to elevate blood sugar values for more than 1 month.

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