Publications by authors named "Cassandra Afseth"

Article Synopsis
  • Phenylketonuria (PKU) is a genetic disorder that leads to dangerous levels of phenylalanine, causing severe health issues like intellectual disabilities and seizures.
  • A study reviewed data from over 200 patients at Lurie Children's Hospital, focusing on the impact of social factors and specific treatments on blood phenylalanine levels.
  • While social vulnerability didn't significantly affect Phe levels, treatment with sapropterin dihydrochloride showed a notable connection, suggesting that social resources and medical support play a crucial role in managing PKU effectively.
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There is growing evidence that offspring receive information about their environment vertically, i.e. from their parents (environmental parental effects or transgenerational plasticity).

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Upregulation of acetate fermentation in plants has recently been described as an evolutionarily conserved drought survival strategy, with the amount of acetate produced directly correlating to survival. However, destructive measurements are required to evaluate acetate-linked drought responses, limiting the temporal and spatial scales that can be studied. Here, C-labeling studies with poplar () branches confirmed that methyl acetate is produced in plants from the acetate-linked acetylation of methanol.

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Plants emit high rates of methanol (meOH), generally assumed to derive from pectin demethylation, and this increases during abiotic stress. In contrast, less is known about the emission and source of acetic acid (AA). In this study, Populus trichocarpa (California poplar) leaves in different developmental stages were desiccated and quantified for total meOH and AA emissions together with bulk cell wall acetylation and methylation content.

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