Publications by authors named "Casper F Zijderhand"

Article Synopsis
  • Left ventricular assist devices (LVADs) are vital for patients with severe heart failure, but their management is mainly at specialized hospitals, making access difficult for those in remote areas.
  • A shared care model (SCM) is being explored to improve collaboration between implanting centers and local hospitals, potentially enhancing patient care.
  • Initial studies suggest that SCMs can improve patient satisfaction and continuity of care, but challenges like staff training and lack of evidence on long-term impacts need to be addressed before broader implementation.
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Background: Right ventricular failure (RVF) is a significant cause of morbidity and mortality in patients with a left ventricular assist device (LVAD). This study is aimed to investigate the influence of a pectus excavatum on early and late outcomes, specifically RVF, following LVAD implantation.

Methods: A retrospective study was performed, that included patients with a HeartMate 3 LVAD at our tertiary referral center.

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This study aimed to explore the potential impact of the angular position of the outflow graft on thromboembolic events and aortic valve regurgitation in people with a left ventricular assist device (LVAD). We analyzed contrast computed tomography (CT) data of patients with LVAD implantation between 2016 and 2021. Three-dimensional reconstructions of the outflow graft and aortic arch were performed to calculate the horizontal (azimuth) angle and vertical (polar) angle, as well as the relative distance between the outflow graft, aortic valve, and brachiocephalic artery.

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Aims: This retrospective study investigated the association between anatomical variations in the aortic arch branching and adverse events, including the risk of cerebrovascular accidents (CVAs), in patients with a left ventricular assist device (LVAD).

Methods: Medical charts were reviewed for all patients with HeartMate 3 LVAD support at our center from 2016 to 2021. Computed tomography scans were evaluated to categorize the variations in the aortic arch branching based on seven different types, as described in the literature.

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In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation (TR), taking into account its dynamic nature, after biatrial orthotopic heart transplant (OHT). All consecutive adult patients undergoing biatrial OHT (1984-2017) with an available follow-up echocardiogram were included. Mixed-models were used to model the evolution of TR.

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Article Synopsis
  • The study investigates the occurrence of external compression of the outflow graft (eOGO) in patients with HeartMate 3 left ventricular assist devices (LVAD), finding a prevalence of 3.0% among 2108 patients over several years of support.
  • Data showed that while eOGO is rare, its incidence increases over time, reaching 9.1% by the fifth year of LVAD support.
  • Clinical outcomes for patients with eOGO included various interventions, with a mortality rate of 17.0% after therapeutic intervention, highlighting the importance of early detection and management.
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Mechanical device malfunction remains a known issue in left ventricular assist devices (LVADs). We investigated the incidence of mechanical device malfunction in the HeartMate II and HeartMate 3 LVADs. We conducted a retrospective study of all HeartMate II and HeartMate 3 LVADs implanted in our center.

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Objectives: In patients supported by a durable left ventricular assist device (LVAD), infections are a frequently reported adverse event with increased morbidity and mortality. The purpose of this study was to investigate the possible association between infections and thromboembolic events, most notable cerebrovascular accidents (CVAs), in LVAD patients.

Methods: An analysis of the multicentre European Registry for Patients Assisted with Mechanical Circulatory Support was performed.

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Objectives: This retrospective study investigated the correlation between the angular position of the left ventricular assist device (LVAD) inflow cannula and relapsing low-flow alarms.

Methods: Medical charts were reviewed of all patients with HeartMate 3 LVAD support for relapsing low-flow alarms. A standardized protocol was created to measure the angular position with a contrast-enhanced computed tomography scan.

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Background: Orthotopic heart transplantation (OHT) is the gold standard treatment in end-stage heart disease. Controversy remains whether bicaval OHT is superior to biatrial OHT in both early and late outcomes. This study aimed to provide an overview of the early and late outcomes in patients who underwent a bicaval or biatrial OHT.

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