Publications by authors named "Caspar N van Emde Boas"
Article Synopsis
- A study explored high-temperature liquid chromatography (HTLC) combined with a screening system to test for bioactive compounds that inhibit the enzyme cathepsin B.
- By using HTLC, researchers reduced methanol usage to 10%, enhancing compatibility with biochemical assays while maintaining reliable detection results with electrospray ionization mass spectrometry.
- The system successfully prevented enzyme deactivation at high temperatures and showed similar sensitivity to conventional methods, demonstrating that inhibitors remained stable and effective under these conditions.
