Publications by authors named "Cason Robbins"
Article Synopsis
- - The study aims to compare the retinal and choroidal structures and microvascular health between individuals with mild to moderate traumatic brain injury (TBI) and healthy controls using optical coherence tomography (OCT) and OCT angiography (OCTA).
- - Results show significant reductions in certain OCTA parameters, including the foveal avascular zone circularity and macular vessel density in TBI patients, particularly those also experiencing posttraumatic stress disorder.
- - The choroidal vascularity index demonstrated potential for indicating the severity of TBI, suggesting that further research could utilize OCT and OCTA as non-invasive tools to monitor retinal and choroidal changes in TBI patients.
Clinical Features Associated With Return to Pre-endophthalmitis Visual Acuity Following Presumed Infectious Endophthalmitis.
Ophthalmic Surg Lasers Imaging Retina
November 2024
Background And Objective: This study aimed to investigate clinical characteristics associated with return to pre-endophthalmitis visual acuity (VA) following treatment for presumed infectious endophthalmitis.
Patients And Methods: This was a retrospective study of 74 eyes with endophthalmitis and VA recorded ≤ 12 weeks before presentation and 6 months after presentation between 2009 and 2018.
Results: Thirty-six of 74 eyes (49%) returned to preendophthalmitis VA.
Article Synopsis
- Frontotemporal dementia (FTD) is a neurodegenerative disorder affecting brain areas linked to cognition and personality, and this study aimed to explore retinal and choroidal changes in FTD patients compared to cognitively normal individuals using specialized imaging techniques.
- The study involved analyzing various retinal imaging parameters in 19 FTD patients and 48 control participants, using methods like optical coherence tomography (OCT) and OCT angiography (OCTA) to assess differences in retinal tissue and blood flow.
- Results indicated significant reductions in macular perfusion density and vessel density in FTD patients, suggesting that retinal changes could serve as potential biomarkers for early detection of FTD, warranting further research using noninvasive imaging techniques.
Article Synopsis
- * A review of data from 2005 to 2020 identified 84 eyes from 77 patients, with 12 eyes being corneal transplant-naïve and receiving primary Kpro.
- * Results show that visual acuity outcomes were similar for both primary and secondary Kpro, though primary Kpro patients tended to have slightly better visual acuity at the final follow-up, with no significant differences in complications like glaucoma or retinal detachment between the two groups.
To evaluate longitudinal peripapillary changes in cognitively normal older adults using optical coherence tomography (OCT) and OCT angiography (OCTA). Participants older than 50 years with no history of neurodegenerative disease or cognitive impairment were prospectively enrolled. OCT and OCTA images were obtained at the first visit and 2 years later.
View Article and Find Full Text PDFPurpose: Report the clinical findings, risk factors, treatment, and visual outcomes associated with endophthalmitis in comparison to culture-positive endophthalmitis associated with non- species.
Methods: A retrospective chart review of adults between 18 and 89 years of age diagnosed with exogenous culture-positive endophthalmitis between January 1, 2009, and January 1, 2018, at the Duke Eye Center (Durham, North Carolina) with at least six months of follow-up from time of initial diagnosis was conducted. Clinical data including patient demographics, ocular history, baseline corrected visual acuity (VA) prior to presentation, time to presentation, presenting exam findings, VA at presentation, presumed etiology of endophthalmitis, medical and surgical management, and VA at the six-month follow-up was extracted and statistically analyzed.
Background: Plasma and cerebrospinal fluid (CSF) levels of p-tau181 have been associated with Alzheimer's disease (AD). The retina and vitreous have shown measurable quantities of phosphorylated tau 181 (p-tau181). The aqueous humor, which can be collected during cataract surgery, may have measurable concentrations of p-tau181.
View Article and Find Full Text PDFPurpose: To utilize ultrawidefield (UWF) imaging to evaluate retinal and choroidal vasculature and structure in individuals with mild cognitive impairment (MCI) compared with that of controls with normal cognition.
Design: Prospective cross sectional study.
Participants: One hundred thirty-one eyes of 82 MCI patients and 230 eyes of 133 cognitively normal participants from the Eye Multimodal Imaging in Neurodegenerative Disease Study.
Purpose: To assess incidence, risk factors, and treatment of retroprosthetic membrane (RPM) formation in eyes following Boston keratoprosthesis (Kpro) implantation and their correlation with glaucoma drainage device placement (GDD).
Methods: A retrospective review was performed on eyes that underwent Kpro type I or II implantation between 2005 and 2020 at a tertiary academic center. Multiple variables were collected including preoperative characteristics, presence of RPM, management of RPM, and outcomes including corrected visual acuity (VA).
Peripapillary Optical Coherence Tomography Angiography in Alzheimer's Disease, Mild Cognitive Impairment, and Normal Cognition.
Ophthalmic Surg Lasers Imaging Retina
February 2024
Objective: This study aimed to identify peripapillary microvascular changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI).
Patients And Methods: In this prospective study, 66 eyes of 36 subjects with AD, 119 eyes of 63 with MCI, and 513 eyes of 265 controls with normal cognition were enrolled. Peripapillary capillary perfusion density (CPD), capillary flux index (CFI), and retinal nerve fiber layer (RNFL) thickness were determined.
Article Synopsis
- The study aimed to analyze changes in retinal and choroidal structures among patients with Huntington's Disease (HD) who possess the mutant huntingtin protein gene (mHtt) compared to healthy individuals.
- It involved a cross-sectional comparison between symptomatic HD patients and cognitively normal controls using advanced imaging techniques to assess various retinal metrics.
- Findings revealed that HD patients had significantly reduced ganglion cell-inner plexiform layer (GCIPL) thickness and smaller foveal avascular zone (FAZ) area, suggesting that retinal changes could serve as biomarkers for neurodegeneration in HD.
Purpose: To investigate retinal vascular characteristics using ultra-widefield (UWF) scanning laser ophthalmoscopy in Parkinson disease (PD).
Methods: Individuals with an expert-confirmed clinical diagnosis of PD and controls with normal cognition without PD underwent Optos California UWF imaging. Patients with diabetes, uncontrolled hypertension, glaucoma, dementia, other movement disorders, or known retinal or optic nerve pathology were excluded.
To evaluate the retinal and choroidal microvasculature and structure in individuals with dementia with Lewy bodies (DLB) compared with controls with normal cognition using optical coherence tomography (OCT) and OCT angiography (OCTA). An institutional review board-approved cross-sectional comparison of patients with DLB and cognitively normal controls was performed. The Cirrus HD-OCT 5000 with AngioPlex (Carl Zeiss Meditec) was used to obtain OCT and OCTA images.
View Article and Find Full Text PDFPurpose: To quantify rate of change of retinal microvascular and choroidal structural parameters in subjects with Parkinson's disease (PD) compared with controls using OCT and OCT angiography (OCTA).
Design: Prospective longitudinal study.
Participants: Seventy-four eyes of 40 participants with PD and 149 eyes of 78 control individuals from the Eye Multimodal Imaging in Neurodegenerative Disease database.
Article Synopsis
- The study aimed to create a machine learning tool that can distinguish between normal cognitive eyes and those with mild cognitive impairment (MCI) using OCT and OCT angiography (OCTA) images.
- A convolutional neural network (CNN) was developed to analyze various eye imaging data, achieving a strong performance with an area under the curve (AUC) of 0.809, indicating good sensitivity (79%) and specificity (83%) in identifying MCI.
- The results suggested that the thickness maps of the ganglion cell-inner plexiform layer (GC-IPL) were more effective for diagnosis compared to OCTA images, emphasizing the importance of image-based data over demographic information for accurate MCI prediction.
Purpose: To compare features of endogenous endophthalmitis associated with injection drug use (IDU) to endogenous endophthalmitis from other etiologies.
Methods: The authors retrospectively collected data on patients with endogenous endophthalmitis due to IDU or other causes from three academic tertiary care centers over a six-year period. Differences in presenting characteristics, culture results, treatment, and visual acuity were compared between groups.
Purpose: To train and test convolutional neural networks (CNNs) to automate quality assessment of optical coherence tomography (OCT) and OCT angiography (OCTA) images in patients with neurodegenerative disease.
Methods: Patients with neurodegenerative disease were enrolled in the Duke Eye Multimodal Imaging in Neurodegenerative Disease Study. Image inputs were ganglion cell-inner plexiform layer (GC-IPL) thickness maps and fovea-centered 6-mm × 6-mm OCTA scans of the superficial capillary plexus (SCP).
Article Synopsis
- The study aimed to evaluate the repeatability of macular OCT angiography (OCTA) parameters among patients with Alzheimer's disease, mild cognitive impairment, Parkinson's disease, and individuals with normal cognition.
- Using high-resolution imaging equipment, researchers measured metrics like perfusion density and vessel density from both 3 mm and 6 mm scans centered on the fovea.
- Results indicated that OCTA metrics showed moderate to good repeatability across all groups, with no significant differences in repeatability between normal cognition and neurodegenerative disease participants.
Purpose: Retinal microvascular abnormalities measured on retinal images are a potential source of prognostic biomarkers of vascular changes in the neurodegenerating brain. We assessed the presence of these abnormalities in Alzheimer's dementia and mild cognitive impairment (MCI) using ultra-widefield (UWF) retinal imaging.
Methods: UWF images from 103 participants (28 with Alzheimer's dementia, 30 with MCI, and 45 with normal cognition) underwent analysis to quantify measures of retinal vascular branching complexity, width, and tortuosity.
Purpose: To assess the repeatability of peripapillary OCT angiography (OCTA) in those with Alzheimer disease (AD), mild cognitive impairment (MCI), Parkinson disease (PD), or normal cognition.
Design: Cross-sectional.
Participants: Patients with a clinical diagnosis of AD, MCI, PD, or normal cognition were imaged.
Purpose: To evaluate differences in the retinal microvasculature and structure and choroidal structure among men and women with Alzheimer's disease (AD) compared with age-matched cognitively normal male and female controls.
Design: Case-control study of participants ≥ 50 years of age.
Participants: A total of 202 eyes of 139 subjects (101 cases and 101 controls).
Purpose Of Review: Artificial intelligence tools are being rapidly integrated into clinical environments and may soon be incorporated into dementia diagnostic paradigms. A comprehensive review of emerging trends will allow physicians and other healthcare providers to better anticipate and understand these powerful tools.
Recent Findings: Machine learning models that utilize cerebral biomarkers are demonstrably effective for dementia identification and prediction; however, cerebral biomarkers are relatively expensive and not widely available.
Purpose: To assess retinal microvascular alterations in individuals with amnestic mild cognitive impairment (MCI) and nonamnestic MCI.
Methods: One hundred twelve eyes of 59 amnestic MCI participants, 32 eyes of 17 nonamnestic MCI participants, and 111 eyes of 56 controls with normal cognition were included. Optical coherence tomography angiography vessel density and perfusion density in the Early Treatment Diabetic Retinopathy Study 3-mm circle and ring were assessed.