Generative AI Analysis of Topics from IMIA Historical Narratives in Medical Informatics.

This describes a project that analyzes and compares the research topics in medical and health informatics emphasized by authors of autobiographical narratives contained in the online IMIA History eBook published in 2021, as the field advanced over the past half century in its international and interdisciplinary dimensions from its early days until the present.

Factors Influencing the Evolution of Topics in Biomedical Informatics.

Our study contributes to the history of international medical informatics through investigating the thematic evolution of the MEDINFO conferences during a period of consolidation and expansion of the discipline. The themes are examined and potential factors influencing the evolutionary developments are discussed.

50 Years of Achievements and Persistent Challenges for Biomedical and Health Informatics and John Mantas' Educational and Nursing Informatics Contributions.

Biomedical and Health Informatics (BMHI) have been essential catalysts for achievements in medical research and healthcare applications over the past 50 years. These include increasingly sophisticated information systems and data bases for documentation and processing, standardization of biomedical data, nomenclatures, and vocabularies to assist with large scale literature indexing and text analysis for information retrieval, and methods for computationally modeling and analyzing research and clinical data. Statistical and AI techniques for decision support, instrumentation integration, and workflow aids with improved data/information management tools are critical for scientific discoveries in the - omics revolutions with their related drug and vaccine breakthroughs and their translation to clinical and preventive healthcare.

Ethics in the History of Medical Informatics for Decision-Making: Early Challenges to Digital Health Goals.

Background: Inclusive digital health prioritizes public engagement through digital literacies and internet/web connectivity for advancing and scaling healthcare equitably by informatics technologies. This is badly needed, largely desirable and uncontroversial. However, historically, medical and healthcare practices and their informatics processes assume that individual clinical encounters between practitioners and patients are the indispensable foundation of clinical practice.

A scientific mind embraces medicine: Donald Lindberg's education and early career.

As a young pathologist, Donald A.B. Lindberg, M.

A Scientific Mind Embraces Medicine: Donald Lindberg's Education and Early Career.

As a young pathologist, Donald A.B. Lindberg, M.

Pandemics: Historically Slow "Learning Curve" Leading to Biomedical Informatics and Vaccine Breakthroughs.

Background: The worldwide tragedy of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic vividly demonstrates just how inadequate mitigation and control of the spread of infectious diseases can be when faced with a new microorganism with unknown pathogenic effects. Responses by governments in charge of public health, and all other involved organizations, have proved largely wanting. Data infrastructure and the information and communication systems needed to deal with the pandemic have likewise not been up to the task.

Evolution of Interdisciplinarity in Medical Informatics in Europe: Patterns from Intertwining Histories.

The IMIA History project book we are co-editing with colleagues from the IMIA History Working Group includes histories of early contributions to medical and healthcare informatics, as described by a sample of pioneers and experts, detailing how their own ideas developed from their work on various topics in the field at the beginnings of their contributions to the field. Its contents serve as a preliminary guide for meta-analyses of how the different contributors state their personal interdisciplinary origins from today's perspectives. In this short article we provide a brief preview of how an analysis of disciplinary characteristics from individual histories can begin to shed light on processes of interdisciplinary evolution of medical informatics in Europe.

Donald A. B. Lindberg: Inspiring Leader and Visionary in Biomedicine, Healthcare, and Informatics.

Background: As Director of the US National Library of Medicine (NLM) for 30 years, Dr. Donald A. B.

Roots of Interdisciplinarity in European Medical Informatics.

The roots of interdisciplinary of medical informatics are sought through the analysis of the themes approached by the pioneers of this field. The data included in the study comes mostly from "personal stories" of European these scientists collected by IMIA WG History as well as from some biographical notes. Most researchers came from the technical-scientific field, but the double specialization was very common.

Beginnings of Artificial Intelligence in Medicine (AIM): Computational Artifice Assisting Scientific Inquiry and Clinical Art - with Reflections on Present AIM Challenges.

Background: The rise of biomedical expert heuristic knowledge-based approaches for computational modeling and problem solving, for scientific inquiry and medical decision-making, and for consultation in the 1970's led to a major change in the paradigm that affected all of artificial intelligence (AI) research. Since then, AI has evolved, surviving several "winters", as it has oscillated between relying on expensive and hard-to-validate knowledge-based approaches, and the alternative of using machine learning methods for inferring classification rules from labelled datasets. In the past couple of decades, we are seeing a gradual but progressive intertwining of the two.

Key Relation Extraction from Biomedical Publications.

Within the large body of biomedical knowledge, recent findings and discoveries are most often presented as research articles. Their number has been increasing sharply since the turn of the century, presenting ever-growing challenges for search and discovery of knowledge and information related to specific topics of interest, even with the help of advanced online search tools. This is especially true when the goal of a search is to find or discover key relations between important concepts or topic words.

50th Anniversary International Medical Informatics Association (IMIA) History Working Group and Its Projects.

The IMIA History Working Group has as its first goal the editing of a volume of contributions from pioneers and leaders in the field of biomedical and health informatics (BMHI) to commemorate the 50th anniversary of IMIA's predecessor IFIP-TC4. This paper describes how the IMIA History WG evolved from an earlier Taskforce, and has focused on producing the edited book of original contributions. We describe its proposed outline of objectives for the personal stories, and national and regional society narratives, together with some comments on the evolution of Medinfo meeting contributions over the years, to provide a reference source for the early motivations of the scientific, clinical, educational, and professional changes that have influenced the historical course of our field.

Decision-Tree Model for Support of Health Policy Choices Based on Pneumococcal Conjugate Vaccine (PCV) Program Outcomes.

Pneumococcal Conjugate Vaccine (PCV) has the potential to save lives in low-income countries. We have developed a computational model and web-based decision support software for comparing cost-benefit tradeoffs from alternative PCV program designs, considering their direct and indirect effects on early childhood populations in resource-poor settings. This supports policy-makers in estimating potential health outcomes and cost-effectiveness of different vaccination program strategies for a wide range of population coverage and vaccine effectiveness assumptions.

Impact of prostate biopsy tumor amount on imaging based prognostics employing transductive semi-supervised regression.

For newly diagnosed prostate cancer patients with a positive biopsy, there are a variety of treatment options to consider. To aid physicians and patients in their decision making, a variety of predictive assays have emerged within the last decade, many of them imaging based. These assays build predictive models for survival analysis to provide personalized risk assessments for the patients.

Research Strategies for Biomedical and Health Informatics. Some Thought-provoking and Critical Proposals to Encourage Scientific Debate on the Nature of Good Research in Medical Informatics.

Background: Medical informatics, or biomedical and health informatics (BMHI), has become an established scientific discipline. In all such disciplines there is a certain inertia to persist in focusing on well-established research areas and to hold on to well-known research methodologies rather than adopting new ones, which may be more appropriate.

Objectives: To search for answers to the following questions: What are research fields in informatics, which are not being currently adequately addressed, and which methodological approaches might be insufficiently used? Do we know about reasons? What could be consequences of change for research and for education?

Methods: Outstanding informatics scientists were invited to three panel sessions on this topic in leading international conferences (MIE 2015, Medinfo 2015, HEC 2016) in order to get their answers to these questions.

Discussion of "The New Role of Biomedical Informatics in the Age of Digital Medicine".

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "The New Role of Biomedical Informatics in the Age of Digital Medicine" written by Fernando J. Martin-Sanchez and Guillermo H. Lopez-Campos [1].

A method for exploring implicit concept relatedness in biomedical knowledge network.

Background: Biomedical information and knowledge, structural and non-structural, stored in different repositories can be semantically connected to form a hybrid knowledge network. How to compute relatedness between concepts and discover valuable but implicit information or knowledge from it effectively and efficiently is of paramount importance for precision medicine, and a major challenge facing the biomedical research community.

Results: In this study, a hybrid biomedical knowledge network is constructed by linking concepts across multiple biomedical ontologies as well as non-structural biomedical knowledge sources.

Discussion of "Computational Electrocardiography: Revisiting Holter ECG Monitoring".

This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Computational Electrocardiography: Revisiting Holter ECG Monitoring" written by Thomas M. Deserno and Nikolaus Marx. It is introduced by an editorial.

Social Media as Catalyzer for Connected Health: Hype or Hope? Perspectives from IMIA Working Groups.

The Internet and social media are becoming ubiquitous technologies that are transforming the health sector. Social media has become an avenue for accessing, creating and sharing health information among patients and healthcare professionals. Furthermore, social media has become a key feature in many eHealth solutions, including wearable technologies, Big Data solutions, eLearning systems, Serious Games, Medical imaging, etc.

A machine learning approach to identify clinical trials involving nanodrugs and nanodevices from ClinicalTrials.gov.

Background: Clinical Trials (CTs) are essential for bridging the gap between experimental research on new drugs and their clinical application. Just like CTs for traditional drugs and biologics have helped accelerate the translation of biomedical findings into medical practice, CTs for nanodrugs and nanodevices could advance novel nanomaterials as agents for diagnosis and therapy. Although there is publicly available information about nanomedicine-related CTs, the online archiving of this information is carried out without adhering to criteria that discriminate between studies involving nanomaterials or nanotechnology-based processes (nano), and CTs that do not involve nanotechnology (non-nano).

Past and next 10 years of medical informatics.

More than 10 years ago Haux et al. tried to answer the question how health care provision will look like in the year 2013. A follow-up workshop was held in Braunschweig, Germany, for 2 days in May, 2013, with 20 invited international experts in biomedical and health informatics.

Assessing the prognoses on Health care in the information society 2013--thirteen years after.

Health care and information technology in health care is advancing at tremendous speed. We analysed whether the prognoses by Haux et al. - first presented in 2000 and published in 2002 - have been fulfilled in 2013 and which might be the reasons for match or mismatch.

The 50(th) Anniversary IMIA History of Medical Informatics Project.

At the meeting of the IMIA Board in 2009 in Hiroshima, it approved an IMIA 50th Anniversary History Project to produce a historical volume and other materials to commemorate the anniversary of the foundation of the predecessor of IMIA-the IFIP-TC4 in 1967. A Taskforce was organized under the direction of Casimir Kulikowski, then the VP for Services of IMIA, and since that time it has met regularly to plan and implement the 50th Anniversary History of IMIA as an edited volume, and as material available online on a Media Presentation Database. The IMIA Taskforce is gathering IMIA-related archival materials, currently accessible through a prototype media repository at Rutgers University in order to help those contributing to the book or writing their own recollections and histories.