Publications by authors named "Casey Snoddy"
Background: NCRAD is a National Institute on Aging (NIA) cooperative grant, awarded to Indiana University since 1990, whose purpose is to serve as a biorepository for AD/ADRD researchers. With 74 participating across 150 unique institutions, NCRAD links specimens to clinical research data. NCRAD maintains over 2 million aliquots from more than 126,000 research participants spanning a wide range of AD/ADRD related phenotypes as well as healthy controls.
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- The LEADS study focuses on understanding the genetic causes of early-onset Alzheimer's Disease (EOAD), specifically in individuals aged 40-64, by screening for known pathogenic variants.
- *Whole exome sequencing of 299 participants found pathogenic variants in 1.35% of EOAD cases and 6.58% of early-onset non-Alzheimer's disease cases, but no gene showed a significant enrichment for rare functional variants.
- *The findings suggest that LEADS may include new genetic variants related to early-onset cognitive impairment, making it an important resource for ongoing Alzheimer's research.*
Article Synopsis
- The Longitudinal Early Onset Alzheimer's Disease Study (LEADS) aims to identify fluid biomarker characteristics specific to early-onset Alzheimer's disease (EOAD).
- The study measured various cerebrospinal fluid (CSF) biomarkers in 165 participants, finding significant differences in certain biomarker levels between EOAD, cognitively normal individuals, and those with early-onset non-AD dementia.
- The results highlight the correlation between biomarkers and cognitive performance, particularly within the EOAD group, providing valuable insights for future clinical trials targeting sporadic EOAD.