Use of digital imaging correlation techniques for full-field strain distribution analysis of implantable devices and tissue in spinal biomechanics research.

Few studies have used optical full-field surface strain mapping to study spinal biomechanics. We used a commercial digital imaging correlation (DIC) system to (1) compare posterior surface strains on spinal rods with those obtained from conventional foil strain gauges, (2) quantify bony vertebral body and intervertebral disc (IVD) surface strains on 3 L3-S cadaveric spines during gold-standard flexibility tests (7.5-Nm flexion-extension and 400-N compression), and (3) report our experience with the application and feasibility of DIC to comprehensively map strain in spinal biomechanics.

The role of tumor-stroma interactions on desmoplasia and tumorigenicity within a microengineered 3D platform.

The tumor microenvironment has been demonstrated to play a crucial role in modulating cancer progression. Amongst various cell types within the tumor microenvironment, cancer associated fibroblasts (CAFs) are in abundance, serving to modulate the biophysical properties of the stromal matrix, through excessive deposition of extracellular matrix (ECM) proteins that leads to enhanced tumor progression. There is still a critical need to develop a fundamental framework on the role of tumor-stromal cell interactions on desmoplasia and tumorigenicity.

The Role of Desmoplasia and Stromal Fibroblasts on Anti-cancer Drug Resistance in a Microengineered Tumor Model.

Introduction: Cancer associated fibroblasts (CAFs) are known to participate in anti-cancer drug resistance by upregulating desmoplasia and pro-survival mechanisms within the tumor microenvironment. In this regard, anti-fibrotic drugs (i.e.