Publications by authors named "Casey L Sautter"
Article Synopsis
- Plasmodium falciparum malaria impacts African children with sickle cell anemia (HbSS), but little is known about how their immune responses compare to children with normal hemoglobin (HbAA) in severe cases.
- A study at Mulago Hospital in Uganda analyzed parasite levels and inflammation markers in children with severe anemia due to malaria, finding that HbSS children had lower sequestered parasite biomass and were more prone to endothelial dysregulation.
- The findings suggest that while HbSS children may experience less immediate parasite accumulation and inflammation, they face higher risks of long-term complications like recurrent malaria and post-discharge mortality, indicating a need for careful long-term monitoring and management.
Background: Sickle cell anemia (SCA), one of most prevalent monogenic diseases worldwide, is caused by a glutamic acid to valine substitution on the beta globin protein of hemoglobin, which leads to hemolytic anemia. Hydroxyurea, the only disease-modifying therapy approved by the Food and Drug Administration for SCA, has proven to be a viable therapeutic option for SCA patients in resource-rich settings, given clinical improvements experienced while taking the medication and its once-daily oral dosing. Significant studies have demonstrated its safety and clinical efficacy among children and adults in developed countries.
View Article and Find Full Text PDF