Association of rhabdomyolysis with renal outcomes and mortality in burn patients.

The contribution of rhabdomyolysis to acute kidney injury (AKI) in the context of burn injury is poorly studied. We sought to determine the impact of rhabdomyolysis on AKI (defined by the AKI Network classification), renal replacement therapy (RRT), and death. Patients admitted to the burn unit at our institution were examined.

Retrospective review of serum creatinine and creatinine-based measures of estimated glomerular filtration rate in an amputee population.

A variety of equations are used to estimate glomerular filtration rate (eGFR). These formulas have never been validated in the setting of traumatic amputation. In this retrospective study involving 255 military personnel with traumatic amputations at a single outpatient center, muscle mass lost was estimated using percentage of estimated body weight lost (% EBWL).

The Acute Kidney Injury Network (AKIN) criteria applied in burns.

In 2007, the Acute Kidney Injury Network (AKIN) developed a modified standard for diagnosing and classifying acute kidney injury (AKI). This classification system is a modification of the previously described risk, injury, failure, loss, and end-stage (RIFLE) criteria. Among other modifications, the AKIN staging requires an absolute serum creatinine change of 0.

Association of AKI with adverse outcomes in burned military casualties.

Background And Objectives: Although associated with increased morbidity and mortality, AKI has not been systematically examined in military personnel injured from combat operations in Iraq and Afghanistan.

Design, Settings, Participants, & Measurements: Patients evacuated from Iraq and Afghanistan to a burn unit were examined. AKI was classified by the Acute Kidney Injury Network (AKIN) and Risk-Injury-Failure-Loss-End Stage (RIFLE) schemas.

Acute water intoxication during military urine drug screening.

Random mandatory urine drug screening is a routine practice in the military. The pressure to produce a urine specimen creates a temptation to consume large volumes of water, putting those individuals at risk of acute water intoxication. This occurs when the amount of water consumed exceeds the kidney's ability to excrete it, resulting in hyponatremia owing to excess amount of water compared to serum solutes.

Fenoldopam use in a burn intensive care unit: a retrospective study.

Background: Fenoldopam mesylate is a highly selective dopamine-1 receptor agonist approved for the treatment of hypertensive emergencies that may have a role at low doses in preserving renal function in those at high risk for or with acute kidney injury (AKI). There is no data on low-dose fenoldopam in the burn population. The purpose of our study was to describe our use of low-dose fenoldopam (0.

Chronic kidney disease management in an academic internal medicine clinic.

Objective: We sought to evaluate the current state of chronic kidney disease (CKD) management in our academic internal medicine clinic.

Methods: A retrospective review was carried out involving all patients with laboratory evidence of CKD enrolled in our clinic. We evaluated the rate of CKD recognition as well as compliance with standard guidelines.

Analysis of novel geometry-independent method for dialysis access pressure-flow monitoring.

Background: End-stage renal disease (ESRD) confers a large health-care burden for the United States, and the morbidity associated with vascular access failure has stimulated research into detection of vascular access stenosis and low flow prior to thrombosis. We present data investigating the possibility of using differential pressure (DeltaP) monitoring to estimate access flow (Q) for dialysis access monitoring, with the goal of utilizing micro-electro-mechanical systems (MEMS) pressure sensors integrated within the shaft of dialysis needles.

Methods: A model of the arteriovenous graft fluid circuit was used to study the relationship between Q and the DeltaP between two dialysis needles placed 2.

Human monocytic ehrlichiosis in a renal transplant patient.

Human ehrlichiosis is an emerging pathogen in immunocompromised patients, potentially leading to increased morbidity compared to immunocompetent patients. A high index of suspicion is imperative and early treatment with doxycycline can be life-saving. We report the case of an immunosuppressed renal transplant patient who was diagnosed with human monocytic ehrlichiosis and successfully treated with doxycycline.

Phosphonate lipid tubules II.

We describe a new chiral tubule-forming lipid in which the C-O-P phosphoryl linkage of the archetypal tubule-forming molecule, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine, "DC(8,9)PC", is replaced by a C-P linkage. Tubule formation with this phosphonate analogue proceeds under the same mild conditions as with DC(8,9)PC and produces similar yields, but synchrotron small-angle X-ray scattering, atomic force microscopy, and optical microscopy show the new tubules to have diameters 1.94 times as great, to be significantly shorter, and to be thinner-walled.