Publications by authors named "Casey A Vasta"
Oligonucleotides
June 2008
Article Synopsis
- Short synthetic oligonucleotides (ODNs) can inhibit cell growth and induce apoptosis, particularly in malignant esophageal cells like OE19, while sparing normal cells.
- Researchers utilized G-rich oligonucleotides (GROs) to specifically trigger apoptosis in these cancer cells through mechanisms measured by various assays, indicating a dependency on the G-quartet structure of these ODNs.
- The results highlight the potential for GROs to selectively eliminate tumor cells without affecting healthy tissues, suggesting a targeted approach for cancer therapy.
