Retention of perampanel in adults with pharmacoresistant epilepsy at a single tertiary care center.

Rationale: Observational data on antiepileptic drugs (AEDs) inform about their use in clinical practice. We describe our clinical experience with perampanel (PER) in a large UK tertiary epilepsy center.

Methods: Adults initiated on PER between October 2012 and March 2015 were followed until they discontinued PER or 10 September 2016.

Perampanel in the general population and in people with intellectual disability: Differing responses.

Purpose: There is a shortfall of suitably powered studies to provide evidence for safe prescribing of AEDs to people with Intellectual Disability (ID). We report clinically useful information on differences in response to Perampanel (PER) adjunctive treatment for refractory epilepsy between ID sub-groups and general population from the UK Ep-ID Research Register.

Method: Pooled retrospective case notes data of consented people with epilepsy (PWE) prescribed PER from 6 UK centres was classified as per WHO guidance into groups of moderate -profound ID, mild ID and General population.