Publications by authors named "Caryn J Ha"
Objective: Although many screening tools, resources, and programs for identifying victims of human trafficking exist, consensus is lacking on which tools are most useful, which have been validated, and whether they are effective. The objectives of this study were to determine what tools exist to identify or screen for victims of human trafficking in health care settings and whether these tools have been validated.
Method: We conducted a scoping review of the literature on human trafficking identification in health care settings following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) protocol for scoping reviews.
Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms.
Christina C Spevak Harold K Elias Lavanya Kannan Mohamed A E Ali Gaëlle H Martin Shanmugapriya Selvaraj Vinagolu K Rajasekhar Guangjie Zhao Caryn J Ha
Cell Stem Cell
May 2020
Article Synopsis
- Hematopoietic stem cells (HSCs) and committed progenitor cells undergo different protein synthesis regulations, impacting their growth and development.
- LSK cells have low overall translation but effectively use specific mRNAs critical for maintaining HSCs, while myeloid progenitors (MPs) translate proteins through an mTOR-independent pathway.
- The study identifies novel mechanisms of translational regulation in HSPCs, highlighting the role of the E3 ubiquitin ligase c-Cbl in controlling mTOR levels and its effect on myeloid cell production.