Toward a More General Consent for the Use of Patients' Biological Material and Health Information for Medical Research-The Patient Perspective.

Biological material and health information from patients are valuable for medical research. Under a "broad" consent model, hospital patients in Norway can consent to their biological material and health information being stored in research biobanks and used for "specific, broadly defined research purposes" within a specified medical research area but not for medical research in general. Patients are asked to provide new consent each time researchers wish to use their material in a different medical research area.

Be a Champion! An Approach to Medical Emergency Response In Situ Simulations in the Outpatient Setting.

Results from a needs assessment conducted by nursing professional development practitioners across several clinics in the Midwest showed current educational methods to prepare for medical emergencies were insufficient. A champion model was used to complete in situ medical emergency response simulations. This proved to be an effective method for staff preparation when resources were limited and identified opportunities for practice improvement.

Generative emulation of weather forecast ensembles with diffusion models.

Uncertainty quantification is crucial to decision-making. A prominent example is probabilistic forecasting in numerical weather prediction. The dominant approach to representing uncertainty in weather forecasting is to generate an ensemble of forecasts by running physics-based simulations under different conditions, which is a computationally costly process.

Stakeholder engagement in European brain research: Experiences of the Lifebrain consortium.

Introduction: Stakeholder engagement remains scarce in basic brain research. However, it can greatly improve the relevance of investigations and accelerate the translation of study findings to policy. The Lifebrain consortium investigated risk and protective factors influencing brain health using cognition, lifestyle and imaging data from European cohorts.

Modeling scatter through sides of island blocks used for intensity-modulated bolus electron conformal therapy.

Purpose: Passive Radiotherapy Intensity Modulators for Electrons (PRIME) devices are comprised of cylindrical tungsten island blocks imbedded in a machinable foam slab within the patient's cutout. Intensity-modulated bolus electron conformal therapy (IM-BECT) uses PRIME devices to reduce dose heterogeneity caused by the irregular bolus surface. Heretofore, IM-BECT dose calculations used the pencil beam redefinition algorithm (PBRA) assuming perfect collimation.

Agronomic and economic implications of cover crop and phosphorus fertilizer management practices for water quality improvement.

Phosphorus (P) fertilization practices and winter cover crops are promoted to protect water quality yet can potentially influence crop yield and profitability. This study examined the impacts of three P fertilizer management practices (no P, fall broadcast P, and spring injected P) and winter annual cover crop use on yields, net returns, and water quality in a no-till corn-soybean rotation. Treatments were replicated in a 4-yr field study where sediment, total P, and dissolved reactive P (DRP) losses in edge-of-field surface runoff were continuously monitored.

Deep learning for twelve hour precipitation forecasts.

Existing weather forecasting models are based on physics and use supercomputers to evolve the atmosphere into the future. Better physics-based forecasts require improved atmospheric models, which can be difficult to discover and develop, or increasing the resolution underlying the simulation, which can be computationally prohibitive. An emerging class of weather models based on neural networks overcome these limitations by learning the required transformations from data instead of relying on hand-coded physics and by running efficiently in parallel.

Analgesia and Sedation in the Prehospital Setting A Critical Care Viewpoint.

Pain is one of the most common complaints of battlefield casualties, and unique considerations apply in the tactical environment when managing the pain of wounded service members. The resource constraints commonly experienced in an operational setting, plus the likelihood of prolonged casualty care by medics or corpsmen on future battlefields, necessitates a review of analgesia and sedation in the prehospital setting. Four clinical scenarios highlight the spectrum of analgesia and sedation that may be necessary in this prehospital and/or austere environment.

Erector Spinae Plane Blocks for Traumatic Rib Fractures: A Prospective, Interventional Study.

Background: Rib fractures are present in 10% of all trauma patients and 30% of patients with significant chest trauma. Pain from rib fractures results in decreased respiratory effort which can lead to atelectasis and potentially pneumonia and death. Pain control is therefore of utmost importance in preventing the complications of rib fractures by improving respiratory function.

Public perceptions of brain health: an international, online cross-sectional survey.

Objectives: To investigate public perspectives on brain health.

Design: Cross-sectional multilanguage online survey.

Setting: Lifebrain posted the survey on its website and social media and shared it with stakeholders.

Cover crop and phosphorus fertilizer management impacts on surface water quality from a no-till corn-soybean rotation.

Best management practices that reduce potential phosphorus (P) loss and provide flexibility in P fertilizer management are needed to help producers protect water quality while maintaining crop yield. This study examined the impacts of P fertilizer management (no P, fall broadcast P, and spring injected P) and cover crop use on annual concentrations and loads of sediment, total P, and dissolved reactive P (DRP) in edge-of-field runoff from a no-till corn (Zea mays)-soybean (Glycine max) rotation in the Central Great Plains, USA, from September 2015 through September 2019. The spring injected P fertilizer treatment generally had 19% less total P and 33% less DRP loss compared to the fall broadcast treatment, confirming the importance of P fertilizer management as a practice for reducing P loss.

Planning and delivery of intensity modulated bolus electron conformal therapy.

Purpose: Bolus electron conformal therapy (BECT) is a clinically useful, well-documented, and available technology. The addition of intensity modulation (IM) to BECT reduces volumes of high dose and dose spread in the planning target volume (PTV). This paper demonstrates new techniques for a process that should be suitable for planning and delivering IM-BECT using passive radiotherapy intensity modulation for electrons (PRIME) devices.

Implementing a Nursing Skills Practice Laboratory Using Social Distancing During the COVID-19 Pandemic.

The COVID-19 pandemic emphasized the importance of preparing nursing staff at healthcare organizations to adequately respond and care for the influx of patients infected with the virus. Training redeployed nursing staff on equipment basics of acute care nursing while following social distancing guidelines posed a challenge. A skills practice laboratory was implemented utilizing a self-learning methodology while adhering to social distancing guidelines.

Useful island block geometries of a passive intensity modulator used for intensity-modulated bolus electron conformal therapy.

Purpose: This project determined the range of island block geometric configurations useful for the clinical utilization of intensity-modulated bolus electron conformal therapy (IM-BECT).

Methods: Multiple half-beam island block geometries were studied for seven electron energies 7-20 MeV at 100 and 103 cm source-to-surface distance (SSD). We studied relative fluence distributions at 0.

Species and termination method effects on phosphorus loss from plant tissue.

Cover crops are often recommended as a best management practice to reduce erosion, weed pressure, and nutrient loss. However, cover crops may be sources of phosphorus (P) to runoff water after termination. Two greenhouse trials were conducted to determine the effects of cover crop species, termination method, and time after termination on water-extractable P (WEP) release from crop biomass.

The Global Brain Health Survey: Development of a Multi-Language Survey of Public Views on Brain Health.

Brain health is a multi-faceted concept used to describe brain physiology, cognitive function, mental health and well-being. Diseases of the brain account for one third of the global burden of disease and are becoming more prevalent as populations age. Diet, social interaction as well as physical and cognitive activity are lifestyle factors that can potentially influence facets of brain health.

Evaluation of prototype of improved electron collimation system for Elekta linear accelerators.

Purpose: This study evaluated a new electron collimation system design for Elekta 6-20 MeV beams, which should reduce applicator weights by 25%-30%. Such reductions, as great as 3.9 kg for the largest applicator, should result in considerably easier handling by members of the radiotherapy team.

Impact of database quality in knowledge-based treatment planning for prostate cancer.

Purpose: This article investigates dose-volume prediction improvements in a common knowledge-based planning (KBP) method using a Pareto plan database compared with using a conventional, clinical plan database.

Methods And Materials: Two plan databases were created using retrospective, anonymized data of 124 volumetric modulated arc therapy (VMAT) prostate cancer patients. The clinical plan database (CPD) contained planning data from each patient's clinically treated VMAT plan, which were manually optimized by various planners.

An improved distance-to-dose correlation for predicting bladder and rectum dose-volumes in knowledge-based VMAT planning for prostate cancer.

The overlap volume histogram (OVH) is an anatomical metric commonly used to quantify the geometric relationship between an organ at risk (OAR) and target volume when predicting expected dose-volumes in knowledge-based planning (KBP). This work investigated the influence of additional variables contributing to variations in the assumed linear DVH-OVH correlation for the bladder and rectum in VMAT plans of prostate patients, with the goal of increasing prediction accuracy and achievability of knowledge-based planning methods. VMAT plans were retrospectively generated for 124 prostate patients using multi-criteria optimization.

Introduction to passive electron intensity modulation.

This work introduces a new technology for electron intensity modulation, which uses small area island blocks within the collimating aperture and small area island apertures in the collimating insert. Due to multiple Coulomb scattering, electrons contribute dose under island blocks and lateral to island apertures. By selecting appropriate lateral positions and diameters of a set of island blocks and island apertures, for example, a hexagonal grid with variable diameter circular island blocks, intensity modulated beams can be produced for appropriate air gaps between the intensity modulator (position of collimating insert) and the patient.

Gravity Wave Spectra in the Lower Stratosphere Diagnosed from Project Loon Balloon Trajectories.

Project Loon has been launching super-pressure balloons since January 2013 to provide worldwide Internet coverage. These balloons typically fly between 18-21 km and provide measurements of winds and pressure fluctuations in the lower stratosphere. We divide 1,560 Loon flights into 3,405 two-day segments for gravity wave analysis.

Improved electron collimation system design for Elekta linear accelerators.

Prototype 10 × 10 and 20 × 20-cm electron collimators were designed for the Elekta Infinity accelerator (MLCi2 treatment head), with the goal of reducing the trimmer weight of excessively heavy current applicators while maintaining acceptable beam flatness (±3% major axes, ±4% diagonals) and IEC leakage dose. Prototype applicators were designed initially using tungsten trimmers of constant thickness (1% electron transmission) and cross-sections with inner and outer edges positioned at 95% and 2% off-axis ratios (OARs), respectively, cast by the upstream collimating component. Despite redefining applicator size at isocenter (not 5 cm upstream) and reducing the energy range from 4-22 to 6-20 MeV, the designed 10 × 10 and 20 × 20-cm applicator trimmers weighed 6.

Young Adults' Belief in Genetic Determinism, and Knowledge and Attitudes towards Modern Genetics and Genomics: The PUGGS Questionnaire.

In this paper we present the development and validation a comprehensive questionnaire to assess college students' knowledge about modern genetics and genomics, their belief in genetic determinism, and their attitudes towards applications of modern genetics and genomic-based technologies. Written in everyday language with minimal jargon, the Public Understanding and Attitudes towards Genetics and Genomics (PUGGS) questionnaire is intended for use in research on science education and public understanding of science, as a means to investigate relationships between knowledge, determinism and attitudes about modern genetics, which are to date little understood. We developed a set of core ideas and initial items from reviewing the scientific literature on genetics and previous studies on public and student knowledge and attitudes about genetics.

A dosimetric comparison of copper and Cerrobend electron inserts.

The purpose of this work was to evaluate differences in dose resulting from the use of copper aperture inserts compared to lead-alloy (Cerrobend) aperture inserts for electron beam therapy. Specifically, this study examines if copper aperture inserts can be used clinically with the same commissioning data measured using lead-alloy aperture inserts. The copper inserts were acquired from .