Modification of brain conductivity in human focal epilepsy: A model-based estimation from stereoelectroencephalography.

Objective: We have developed a novel method for estimating brain tissue electrical conductivity using low-intensity pulse stereoelectroencephalography (SEEG) stimulation coupled with biophysical modeling. We evaluated the hypothesis that brain conductivity is correlated with the degree of epileptogenicity in patients with drug-resistant focal epilepsy.

Methods: We used bipolar low-intensity biphasic pulse stimulation (.

A comparative dataset: Bridging COVID-19 and other diseases through epistemonikos and CORD-19 evidence.

The COVID-19 pandemic has underlined the need for reliable information for clinical decision-making and public health policies. As such, evidence-based medicine (EBM) is essential in identifying and evaluating scientific documents pertinent to novel diseases, and the accurate classification of biomedical text is integral to this process. Given this context, we introduce a comprehensive, curated dataset composed of COVID-19-related documents.

Performance of a Point of Care Test for Detecting IgM and IgG Antibodies Against SARS-CoV-2 and Seroprevalence in Blood Donors and Health Care Workers in Panama.

Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, which has reached 28 million cases worldwide in 1 year. The serological detection of antibodies against the virus will play a pivotal role in complementing molecular tests to improve diagnostic accuracy, contact tracing, vaccine efficacy testing, and seroprevalence surveillance. Here, we aimed first to evaluate a lateral flow assay's ability to identify specific IgM and IgG antibodies against SARS-CoV-2 and second, to report the seroprevalence estimates of these antibodies among health care workers and healthy volunteer blood donors in Panama.

Biophysical Modeling for Brain Tissue Conductivity Estimation Using SEEG Electrodes.

Objective: We aimed at providing an accurate estimation of human brain tissue electrical conductivity in clinico, using local, low-intensity pulsed stimulation.

Methods: Using the quasi-static approximation of Maxwell equations, we derived an analytical model of the electric field generated by intracerebral stereotactic-EEG (SEEG) electrodes. We coupled this electric field model with a model of the electrode-electrolyte interface to provide an explicit, analytical expression of brain tissue conductivity based on the recorded brain tissue response to pulse stimulation.

[Considerations on the new Chilean law about rights and duties of patients].

After years of discussion by the Chilean legislature, the Law Nº 20.584, which regulates health care related rights and duties of people, entered into force in Chile in October 2012. This bill represents an important step in the recognition and protection of health care related rights, welfare, dignity and duties of persons.

A young man with myelosuppression caused by clindamycin: a case report.

Introduction: Clindamycin is used to treat various bacterial infections, but its administration can cause anaphylaxis, liver reactions, pseudomembranous colitis, and peripheral blood cytopenias (anemia, neutropenia, and thrombocytopenia), alone or in combination. We report the case of a patient with a recurrent infection of the tonsils who received clindamycin. Pancytopenia, a previously unreported hematological disorder related to clindamycin use, was observed in conjunction with the infection and clindamycin treatment.

Double dissociation between visual recognition and picture naming: a study of the visual language connectivity using tractography and brain stimulation.

Background: Study of the corticosubcortical functional anatomy of reading and picture naming.

Objective: To study the role of the left basal occipitotemporal area and its white matter pathways.

Methods: Three patients underwent awake surgery for lesions in the left basal posterotemporal region with intraoperative electrostimulations.

[Adult Still's disease. A great simulator. Retrospective review of 20 patients].

Background: Adult Still's disease is an inflammatory disorder characterized by quotidian fevers, and an evanescent rash. Its presentation can be acute or subacute.

Aim: To report our experience with Adult Still's disease.

[Physicians and professionalism. Patients and information].

In the present time, the advances in sciences brought by technology are worshiped. This contributes to dehumanize human relationships. Medical profession is a commitment to oneself, society and social justice.

[Methotrexate use in patients with systemic lupus erythematosus].

Background: In the past ten years, methotrexate (MTX) has appeared as an alternative for the treatment of systemic lupus erythematosus (SLE).

Aim: To evaluate the use of MTX and the results of treatment in a group of patients with SLE.

Patients And Methods: Retrospective review of 426 files of patients with SLE.

[Ethical reflections on errors in medicine].

It is usually inevitable to save the physician-patient relationship from the effects of medical errors. It is so because either the professional responsibility, the patients trust and the principles that govern the medical action are compromised by such events. The possibility to learn from it, prevent its appearance, improve the procedures and curtail its consequences, is linked to developing ethical attitudes to overcome these circumstances without further legal accountability.

[Rheumatoid arthritis. Therapeutic efficacy of methotrexate and its hepatotoxic effects].

The efficacy and toxicity (specially hepatic) of methotrexate in low doses (7.5 mg/week) was prospectively assessed in 21 patients with rheumatoid arthritis refractory to treatment with gold or penicillamine, during two years. Three patients were prematurely withdrawn from the protocol.

[Adult non-insulin-dependent diabetic: limitation of articular mobility and soft tissue involvement].

Periarticular involvement and joint mobility were investigated in 100 non insulin dependent diabetic patients, compared to 100 healthy control subjects of similar age and sex. Periarticular involvement was much more common in diabetics (p < 0.01) including limitation of joint mobility (hands) (40% vs 9%), Dupuytren (29% vs 2%), palmar synovitis (59% vs 7%) and capsulitis (16% vs 1%).

[Juvenile dermatomyositis: clinical manifestations and laboratory tests].

Juvenile dermatomyositis (JDM) is a chronic, inflammatory degenerative entity with multisystemic involvement, particularly of skin and striated muscle. This is a description of the clinical features, laboratory findings and treatment results in 10 children with JDM which were under control along a 14 years period (1974-1988) in a general hospital at metropolitan Santiago, Chile. Onset was insidious in 8 cases and acute in the remaining patients.

[Systemic lupus erythematosus and pregnancy. Clinical experience in 57 patients].

We reviewed the obstetric history of 57 patients with systemic lupus erythematosus (SLE). The number and outcome of pregnancies before and after the diagnosis of SLE was recorded. The clinical course of 21 patients who became pregnant during the observation period was noted.

Successful renal transplantation in polyarteritis nodosa.

Hemodialysis and renal transplantation were performed in a patient with end stage renal disease caused by polyarteritis nodosa. Severe peripheral neuropathy developed during hemodialysis. Five years after transplantation, marked improvement of the neuropathy associated with adequate function of the allograft has been noted.