Analyses of the Genetic Diversity and Population Structures of spp. Clinical Isolates from Paraíba, Brazil.

Unlabelled: Sporotrichosis is a subcutaneous mycosis of global distribution, capable of affecting both humans and animals, and caused by species of the genus spp. This study aimed to evaluate the genetic diversity and mating type distribution of clinical isolates of human sporotrichosis in Paraíba, Brazil, to better understand the population structure, epidemiology, and diversification of this pathogen, as well as to explore possible transmission routes.

Methods: A total of 36 clinical isolates were morphologically identified, and clinical and demographic data were collected.

Domestic and external violence, parental neglect, and social sanctions among crack users: A cross-sectional study exploring the role of gender.

Background: Substance Use Disorders are often associated with significant levels of domestic and external violence registered among abusers. This investigation aimed to evaluate the Domestic Violence Involvement (DVI) and related gender differences among Crack Cocaine Users in Brazil.

Methods: For this purpose, a secondary data analysis of a multicenter cross-sectional study involving 780 Crack Cocaine Users from 6 Brazilian capitals was performed.

Pseudo-Sciatica Pain Due to a Biceps Femoris Muscle Tear.

Hamstring injuries (HSIs) are common among athletes, particularly in high-speed sports, and are frequently associated with prolonged recovery periods and a high recurrence rate. This study presents a 36-year-old male with sciatica-like symptoms following an acute hamstring tear during an amateur football match. The patient experienced this pain two weeks after the injury, suggesting potential sciatic nerve involvement.

The Mediating Role of Sexual Boredom in Women's Sexual Desire and Satisfaction.

Sexual boredom in women is associated with various levels and dimensions of sexual desire, as well as lower sexual and relationship satisfaction. However, the directionality of these relationships remains unclear. This study aimed to investigate whether sexual boredom mediates the relationship between partner and attractive-other sexual desire and sexual and relationship satisfaction in a sample of 1155 Portuguese women in long-term monogamous relationships.

Aging promotes an increase in mitochondrial fragmentation in astrocytes.

Introduction: Brain aging involves a complex interplay of cellular and molecular changes, including metabolic alterations and the accumulation of senescent cells. These changes frequently manifest as dysregulation in glucose metabolism and mitochondrial function, leading to reduced energy production, increased oxidative stress, and mitochondrial dysfunction-key contributors to age-related neurodegenerative diseases.

Methods: We conducted experiments on two models: young (3-4 months) and aged (over 18 months) mice, as well as cultures of senescent and control mouse astrocytes.

Well-managed grass is a key strategy for carbon storage and stabilization in anthropized Amazon soils.

Soils under anthropic use in the Amazon region are often associated with soil carbon (C) stock losses. More recently, the restoration of degraded pastures and the introduction of integrated systems have changed this pattern, and soil C accumulation is often observed. This study evaluated an 11-year field experiment to quantify soil C changes and elucidate C stabilization mechanisms in areas under anthropic uses in the southern Amazon of Brazil.

Unveiling the embryo structure in Bromeliaceae Juss. (Poales): morphological diversity, anatomy, and character evolution.

Background And Aims: Recent studies have documented numerous morphoanatomical variations for the seed coat in Bromeliaceae. However, the structural diversity and character evolution of the embryo within this family remain largely unexplored. Given the embryo's significance in plant diversification, this research aims to investigate the morphology and key anatomical features of Bromeliaceae embryos, providing insights into character evolution, taxonomic applications, and reproductive biology.

Antimicrobial and Anti-inflammatory Activity of Bauhinia pulchella Extract Fractions.

This study investigates the antimicrobial and anti-inflammatory activities of fractions from the stem extract of Bauhinia pulchella Benth. The ethanolic extract was fractionated using column adsorption chromatography, resulting in a hexane fraction (J1) and a dichloromethane fraction (J2), both rich in terpenes and steroids. Characterization was performed using gas chromatography coupled with mass spectrometry (GC-MS).

Sex Differences in Patients with Stroke: A Hospital-Based Multicenter Prospective Study in Brazil.

Introduction: Stroke in Brazil disproportionately affects women, despite men having higher age-adjusted incidence and mortality rates. Women's longer lifespan contributes to their increased stroke burden, particularly among older individuals.

Objective: This study examines sex disparities in stroke epidemiology and treatment in Fortaleza, Brazil, addressing the lack of sex-specific stroke data.

Anti-vitamin D antibodies.

Background: Low vitamin D levels are commonly observed in autoimmune diseases, suggesting a potential role in disease pathogenesis. The presence of anti-vitamin D antibodies may contribute to these deficiencies and influence autoimmune processes.

Objective: To review and analyze studies investigating the occurrence of anti-vitamin D antibodies in autoimmune diseases.

Dietary antioxidant capacity is inversely associated with F2- isoprostane and body fat percentage in elite soccer referees.

Background Dietary antioxidant Capacity (DaC) has been used as a tool for predicting plasma and dietary antioxidant concentrations. However, the DaC association with oxidative stress (OS) and body composition parameters is an unexplored area, mainly in physically active individuals. Given the potential for increased OS in physically active individuals, it becomes crucial to investigate this association.

Impact of adding warm asphalt mix additives on recycling milled coatings: performance evaluation.

The use of warm mix asphalt (WMA) and reclaimed asphalt pavement (RAP) technologies presents challenges in optimizing binder activation and mechanical performance in asphalt mixtures. This study aimed to evaluate the effects of three WMA additives (sunflower oil, WarmGrip®, and natural zeolite) and different RAP contents (30% and 70%) on the rheological and mechanical properties of recycled asphalt mixtures. The research focused on assessing the degree of RAP binder activation, determining the extent of partial activation, and analyzing the impact on tensile strength, moisture resistance, modulus, fatigue life, and deformation resistance.

High-resolution targeted mass spectrometry for comprehensive quantification of sphingolipids: clinical applications and characterization of extracellular vesicles.

Sphingolipids (SL), a class of membrane lipids, play important roles in numerous biological processes. Their significant structural diversity poses challenges for accurate quantification. To address this, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has emerged as a powerful tool for sphingolipidomics, capable of profiling these lipids comprehensively.

Derotational Corrective Osteotomy for Pediatric Forearm Malunion: A Case Report.

In this case report, we describe an eight-year-old boy with both-bone forearm diaphyseal fracture that was treated conservatively after closed reduction with manipulation. Nine months after the injury, he returned to consultation, presenting a rotational deformity of the forearm and 20° of pronosupination limitation. He was submitted to corrective osteotomies, using three-dimensional (3D) planning and templating, using a double approach, and fixation with a four screw holes plate in each osteotomy.

Repercussions of Long-Term Naproxen Administration on LPS-Induced Periodontitis in Male Mice.

Aims: Chronic periodontitis is the sixth most prevalent disease worldwide and the leading cause of tooth loss in adults. With growing attention on the role of inflammatory and immune responses in its pathogenesis, there is an urgent need to evaluate host-modulatory agents. Non-steroidal anti-inflammatory drugs (NSAIDs) drugs play a crucial role in managing inflammatory conditions.

Challenges of the Biopharmaceutical Industry in the Application of Prescriptive Maintenance in the Industry 4.0 Context: A Comprehensive Literature Review.

The biopharmaceutical industry has specificities related to the optimization of its processes, the effectiveness of the maintenance of the productive park in the face of regulatory requirements. and current concepts of modern industry. Current research on the subject points to investments in the health area using the current tools and concepts of Industry 4.

Toxicity and Dermatokinetic Analysis of Ibrutinib in Human Skin Models.

Ibrutinib (IBR) is a tyrosine kinase inhibitor under investigation in preclinical and clinical settings as an alternative treatment for melanoma. Nevertheless, the limited oral bioavailability of IBR and the need for high doses of the drug to kill melanoma cells are major drawbacks for this purpose. Considering that melanoma is restricted to the skin at early stages, the topical application of IBR might constitute an effective and safer administration route.

Network Analysis of Pathogenesis Markers in Murine Chagas Disease Under Antimicrobial Treatment.

Chagas disease (CD), a disease affecting millions globally, remains shrouded in scientific uncertainty, particularly regarding the role of the intestinal microbiota in disease progression. This study investigates the effects of antibiotic-induced microbiota depletion on parasite burden, immune responses, and clinical outcomes in BALB/c mice infected with either the Colombiana or CL Brener strains. Mice were treated with a broad-spectrum antibiotic cocktail before infection, and parasite burden was quantified via qPCR at 30 and 100 days post-infection (dpi).

New Epitopes for the Serodiagnosis of Human Borreliosis.

Lyme disease, a zoonotic infection caused by the bacterium , is transmitted to humans through the bites of infected ticks. Its diagnosis primarily relies on serological methods; however, the existing borreliosis techniques have shown a variable sensitivity and specificity. Our study aimed to map IgG epitopes from five outer membrane proteins (Omp) from [Filament flagellar 41kD (PI1089), flagellar hook-associated protein (Q44767), Flagellar hook k2 protein (O51173), Putative Omp BURGA03 (Q44849), and 31 kDa OspA (P0CL66)] lipoprotein to find specific epitopes for the development of accurate diagnosis methods.

Anti-lipoprotein lipase antibodies: A review.

Background: Dyslipidemia is described in several autoimmune conditions. Lipoprotein lipase (LPL) is responsible for triglyceride breakdown. Anti-LPL antibodies have been described.

Cross-Cultural Validation of the Sexual Desire Inventory (SDI-2) in 42 Countries and 26 Languages.

Sexual desire is a complex construct with important implications for sexual functioning and well-being. In this research, we translated the Sexual Desire Inventory (SDI-2), a widely used scale for assessing sexual (desire), into 25 languages from English and used data from the International Sex Survey (ISS) to (a) investigate its psychometric properties (i.e.

Jerked beef as an ultraprocessed convenience food: Desalting strategies to minimize the impact on lipid and protein oxidation.

Jerked beef (JB) is a high-protein convenience food but shows high degree of oxidation owing to its severe ultraprocessing. This study aimed to investigate the effect of desalting processes on oxidative stability of JB. JB were submitted to five desalting procedures: immersion in water at room temperature for 12 h without changing the water (AT12); immersion in water at room temperature for 12 h followed by boiling for 30 min and changing the water between the two procedures (AT12 + C30); immersion in boiled water for 10, 20, and 30 min (C10, C20, and C30, respectively).