Aberrant E-cadherin Expression in Lobular Carcinoma In Situ: A Comprehensive Immunohistochemical Evaluation of N-terminal, Extracellular, and C-terminal E-cadherin Domains.

E-cadherin (E-cad) immunohistochemistry is commonly used to distinguish lobular carcinoma in situ (LCIS) from ductal carcinoma in situ in histologically uncertain or ambiguous cases. Although most LCIS cases show an absence of E-cad expression on the neoplastic cell membranes, some show aberrant E-cad expression which can lead to diagnostic confusion. Awareness and understanding of the frequency, patterns, and distribution of aberrant E-cad staining in LCIS is crucial to achieving a correct diagnosis.

Repair bond strength of composite resin to CAD/CAM glass-ceramic: influence of cleaning methods, surface treatments, and aging.

Objective: To evaluate the influence of different cleaning methods, surface treatments, and aging on the repair bond strength to a CAD/CAM glass-ceramic.

Materials And Methods: Forty-eight lithium disilicate CAD/CAM ceramic blocks were fabricated, sintered, and embedded in acrylic resin. After contamination with human saliva, they were divided according to the factors "Cleaning method" (Control-water/air spray, Air-particle abrasion with AlO, Ivoclean cleaning paste), "Surface treatment" (5% Hydrofluoric acid-HF + Silane, Monobond Etch & Prime-MEP), and "Aging" (thermocycling, no thermocycling).

Dose-related effects of eugenol: Exploring renal functionality and morphology in healthy Wistar rats.

Eugenol has pharmacological properties, but its impact on renal function is limitedly studied. Thus, this study evaluated the effects of eugenol at 10, 20, and 40 mg kg, administered via gavage for 60 days, on histological, biochemical, oxidative, and proteomic parameters in rat kidneys. Adult Wistar rats treated with 10 mg kg of eugenol had kidneys with low total antioxidant capacity, high nitric oxide content, and high percentual of blood vessels, with no damage to renal function or morphology.

Nutritional and technological potential of umbu-caja and soursop co-product flours.

Umbu-caja and soursop from the Northeast region of Brazil are rich in nutrients and bioactive compounds and are widely processed by the fruit agroindustry. However, there is a lack of research examining the composition and nutritional/technological potential of these co-product fruits. The present study evaluated the nutritional and technological characteristics of umbu-caja and soursop co-product flours (UCF and SCF, respectively), in addition to cytotoxicity in healthy cells.

Cavitary Pulmonary Tuberculosis in an Infant.

Tuberculosis (TB) continues to pose a significant health challenge globally and in Portugal. Diagnostic challenges persist, especially in infants, where TB often presents with atypical symptoms. A previously healthy three-month-old male infant from Vila Nova de Famalicão, Portugal, was admitted with cough, rhinorrhea, respiratory distress, and high-grade fever.

Effectiveness of a new thermal insulation blanket in the control of inadvertent perioperative hypothermia and comfort: a randomized controlled trial.

Background: Disturbances in the thermoregulatory system can precipitate inadvertent hypothermia in patients undergoing surgeries lasting over 60 min, causing serious complications in the recovery process. Cutaneous thermal protection is relevant for the control of temperature of patients in the perioperative setting. The standard thermal protection widely utilized is an electric forced warm air blanket.

Terpyridine-based ruthenium complexes containing a 4,5-diazafluoren-9-one ligand with light-driven enhancement of biological activity.

There has been growing effort in the scientific community to develop new antibiotics to address the major threat of bacterial resistance. One promising approach is the use of metal complexes that provide broader opportunities. Among these systems, polypyridine-ruthenium(II) complexes have received particular attention as drug candidates.

Complications of acute rhinossinusitis. A clinical radiological review.

Acute rhinossinusitis is defined as a symptomatic inflammation of the nasal fossa and paranasal sinuses. The diagnosis of this disease is clinical and usually does not require imaging evaluation. However, when there is a suspicion of a complication or even for surgical planning, imaging is of primordial importance.

High genetic structure of Spondias mombin in Brazil revealed with SNP markers.

Spondias mombin L. (Anacardiaceae) is an arboreal and allogamous fruit tree native from southern Mexico to southeastern Brazil, with great potential for economic exploitation. This study aimed to evaluate the structure and genomic diversity of yellow mombin accessions collected in nine locations in Brazil using Single Nucleotide Polymorphisms (SNP) markers.

An Overview of Monkeypox Virus Detection in Different Clinical Samples and Analysis of Temporal Viral Load Dynamics.

Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV), and since May 2022, tens of thousands of cases have been reported in non-endemic countries. We aimed to evaluate the suitability of different sample types for mpox diagnostic and assess the temporal dynamics of viral load. We evaluated 1914 samples from 953 laboratory-confirmed cases.

Alveolar Bone Tissue Engineering Using Deciduous Dental Pulp Stem Cells in a Patient with Cleft Lip and Palate.

The use of tissue bioengineering strategies in dentistry has gained relevance. Many studies indicate that stem cells associated with biomaterials can regenerate intraoral tissues and have been applied to patients with cleft lip and palate (CLP). One of the treatments is alveolar bone reconstruction through bone grafts, where the bone is removed from the donor site and placed in the alveolar cleft.

Radiology resident proficiency in identifying misplaced lines, tubes, and devices: a simulation-based study using WIDI SIM.

Purpose: Accurate placement of medical devices is crucial in critical care to prevent severe complications. This study aims to evaluate radiology residents' proficiency in identifying four specific critical misplacements of medical devices using the Wisdom in Diagnostic Imaging Simulation (WIDI SIM).

Methods: A retrospective analysis was conducted on 1,102 responses from radiology residents who participated in the WIDI SIM between 2010 and 2022.

Child Abdominal Distension Due to a Massive Retroperitoneal Lymphangioma: A Cyto-Histopathological and Clinical Correlation.

Lymphangiomas are rare benign tumors that result from lymphatic vessel malformations and/or obstructions commonly on the neck and armpits, being rare in the retroperitoneal space. We report a case of a healthy 25-month-old male with a six-month history of abdominal distension and recurrent episodes of diarrhea who was clinically diagnosed with giardiasis. The complementary evaluation showed a cystic formation occupying the whole abdominal cavity and implanted at the abdominal retroactivity.

Impact of the Covid-19 pandemic on the maternal mortality rate in Brazil: trend and spatial distribution.

Objective: To analyze the impact of the Covid-19 pandemic on the Maternal Mortality Ratio in Brazil from 2018 to 2021.

Method: Ecological time series study, which analyzed the trend and spatial distribution of maternal deaths from 2018 to 2021, with data obtained from the Mortality and Live Birth Information System. The Maternal Mortality Ratio values were subjected to Prais-Winsten linear regression analysis using Stata program, version 14.

A single-center case study series assessing the effect of selumetinib use in patients with neurofibromatosis-related plexiform neurofibromas.

Background: Neurofibromatosis type 1 (NF1) is a common genetic disorder of phenotypic variability with age-dependent penetrance. This study describes the diagnosis, clinical characterization, management, and outcomes of a large patient cohort with plexiform neurofibroma (PN) treated with selumetinib in a real-world clinical setting.

Methods: This single-center observational study consecutively enrolled patients with NF1-PN treated with selumetinib from April 2018 to 2023.

Synergistic Effects of Dietary Tryptophan and Dip Vaccination in the Immune Response of European Seabass Juveniles.

Vaccination is an effective, cost-efficient method to preventing disease outbreaks. However, vaccine procedures can induce adverse reactions due to stress, increasing plasma cortisol in the short term. In this context, tryptophan may prove to be fundamental as it has been demonstrated to have various desirable neuroendocrine attributes in different fish species.

Cretaceous bird from Brazil informs the evolution of the avian skull and brain.

A dearth of Mesozoic-aged, three-dimensional fossils hinders understanding of the origin of the distinctive skull and brain of modern (crown) birds. Here we report Navaornis hestiae gen. et sp.

A Freidsonian Analysis of The Professional trajectories of Public Health Nursing Specialists in Minas Gerais, Brazil, 1988-1992.

Objective: To analyze the contributions of the Public Health Nursing Specialization Course (1988-1992) of Universidade Federal de Minas Gerais in improving the expertise and professional status of its graduates.

Method: Historical and social study in the history of nursing and expertise. The sources included 20 registration forms, enrollment documentation of graduates, and three course documents collected in the Memory Center of Escola de Enfermagem da Universidade Federal de Minas Gerais, combined with Lattes/CNPq curricula and analyzed through Eliot Freidson's Sociology of Professions.

Ethnobotanical Surveys of Plants Used by Quilombola Communities in Brazil: A Scoping Review.

Quilombola communities play a crucial role in maintaining biodiversity through traditional management models. The use of medicinal plants within these communities reflects a deep reservoir of knowledge, passed down through generations. The objective of this study was to conduct a scoping review to systematically analyze and synthesize the existing literature on the medicinal plants used by Quilombola communities in Brazil, with a focus on their therapeutic applications and cultural significance.

Short-term reoxygenation is not enough for the recovery of soybean plants exposed to saline waterlogging.

The ability of plants to recover after stressful events is crucial for resuming growth and development and is a key trait when studying stress tolerance. However, there is a lack of information on the physiological responses and the time required to restore homeostasis after the stress experience. This study aimed to (i) enhance understanding of soybean photosynthesis performance during saline waterlogging and (ii) investigate the effects of this combined stress during the reoxygenation and recovery period.