Adjusting ventilator off-cycling in invasively ventilated COPD patients needs comprehensive adjustments.

Background: Patient-ventilator asynchrony that prolongs weaning and increases morbidity and mortality is common during invasive ventilation of patients with chronic obstructive pulmonary disease (COPD). In this context, the inspiratory cycling criteria (iCC) of the ventilator during assisted pressure support (PS) ventilation is a poorly acknowledged key factor. We investigated the changes of flow and pressure parameters that resulted from varying the iCC in a simulated COPD lung model.

Patient-Ventilator Interaction During Noninvasive Ventilation in Simulated COPD.

Background: During noninvasive ventilation (NIV) of COPD patients, delayed off-cycling of pressure support can cause patient ventilator mismatch and NIV failure. This systematic experimental study analyzes the effects of varying cycling criteria on patient-ventilator interaction.

Methods: A lung simulator with COPD settings was connected to an ICU ventilator via helmet or face mask.