Publications by authors named "Carsten Koehn"
Combination effects of (tri)azole fungicides on hormone production and xenobiotic metabolism in a human placental cell line.
Int J Environ Res Public Health
September 2014
Article Synopsis
- Consumers ingest various pesticide residues through their diets, leading to EU regulations that assess both individual pesticide effects and their combinations, which poses a challenge for toxicology.
- This study focuses on the additive effects of various antifungal (triazole) pesticides and other chemical class pesticides on hormone production in a human placental cell line, revealing pronounced inhibition of progesterone production with triazoles.
- While triazoles and the fungicide prochloraz showed hormone-related effects, other pesticides like chlorpyrifos and triflusulfuron-methyl did not impact steroid hormone production or CYP enzyme expression significantly.