Publications by authors named "Carson Leong"
Introduction: Patients requiring treatment for second cancer incidences present unique radiotherapy plan development challenges. Historical dose delivered to organs at risk must be accounted for to properly estimate lifetime toxicity risks, but historical dose delivered to the region now occupied by tumours does not contribute to the prescription dose. Treatment planning systems permit inclusion of a base plan but do not provide the ability to manipulate it.
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- The study aimed to compare the quality of life (QOL) between standard chemoradiotherapy (SFX) and altered fractionation radiotherapy (AFX) combined with the drug panitumumab (PMab) for patients with squamous cell head-neck carcinoma.
- It involved 320 patients and assessed their QOL using various questionnaires at different intervals, but after one year, no significant difference in QOL changes was observed between the two treatment arms.
- The results concluded that PMab with AFX did not lead to any lasting improvements in QOL or swallowing when compared to SFX with cisplatin.
Purpose: Based on our demonstration of a circadian rhythm in the human oral mucosa cell cycle, with most cells in the G(1) phase in the morning and M phase at night, we hypothesized that morning radiotherapy (RT) would lead to less oral mucositis than afternoon RT.
Methods And Materials: A total of 216 patients were randomized to morning (8-10 AM) vs. afternoon (4-6 PM) RT and stratified by radiation dose, smoking status, and center.
Background: Breast conservative surgery (CS) with radiotherapy (RT) is the most commonly used treatment for early-stage breast carcinoma. However, there is controversy regarding the importance of the pathologic margin status on the risk of ipsilateral breast tumor recurrence (IBTR). The current study evaluated the effect of the pathologic margin status on IBTR rates in a cohort of women with lymph node-negative breast carcinoma treated with CS and RT.
View Article and Find Full Text PDFPurpose: This multi-institutional Phase III randomized study compared 10 Gy single-fraction radiotherapy (RT) with 20 Gy in five fractions in the palliation of thoracic symptoms from lung cancer.
Methods And Materials: The primary end point was palliation of thoracic symptoms at 1 month after RT, evaluated by a patient-completed daily diary card. Secondary end points included quality of life, toxicity, and survival.