Publications by authors named "Carson J Swain"
Article Synopsis
- Researchers developed a new drug delivery system using extracellular vesicles (EVs) to transport the enzyme TPP1 to treat Batten disease.
- A single injection of TPP1-loaded EVs showed over 20% delivery efficiency to the brain and demonstrated cumulative therapeutic effects in a mouse model.
- The EV-TPP1 treatment activated the autophagy pathway, reduced harmful lipofuscin aggregates, decreased inflammation, and improved neuron survival, highlighting the potential for enhancing brain health.
Extracellular vesicles (EVs) are cell-derived nanoparticles that facilitate transport of proteins, lipids, and genetic material, playing important roles in intracellular communication. They have remarkable potential as non-toxic and non-immunogenic nanocarriers for drug delivery to unreachable organs and tissues, in particular, the central nervous system (CNS). Herein, we developed a novel platform based on macrophage-derived EVs to treat Parkinson disease (PD).
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