Immunohistochemical localization of filaggrin in benign and malignant lesions of the human oral mucosa.

Filaggrin is a protein normally present in the granular and horny layer of stratified squamous epithelia. We studied the presence of this protein in 83 benign lesions and in 73 cases of malignant epithelial tumours of the oral cavity and investigated its possible role as an immunohistochemical marker. The immunohistochemical technique was based on the P.

[Clinical considerations of jejunal carcinoma].

The carcinoma of the jejunum represents 3-6.5% of gastric intestinal tumors and 33-50% of small intestine carcinomas. The observation of a case of jejunum carcinoma has offered the authors the idea for a critical revision on the subject.

Peripheral neuropathy in amyotrophic chorea-acanthocytosis.

We investigated involvement of the peripheral nervous system in 6 patients with amyotrophic chorea-acanthocytosis. Electromyographic and neurographic findings, and pathological changes as demonstrated by examination of biopsy specimens of muscle and sural nerve indicate that most patients had an axonal sensorimotor polyneuropathy with more pronounced involvement of the distal portion of the nerves. Results obtained in one patient raised the question of an anterior horn cell disorder.

Adult-onset centronuclear myopathy: evidence against a neurogenic pathology.

A case of sporadic adult-onset centronuclear myopathy is presented. EMG was myopathic and nerve conduction study entirely normal. Single-fiber electromyography showed a normal percentage of potential pairs with abnormal jitter, slightly increased mean jitter value, no blocking and normal fiber density.

[Malignant fibrous histiocytoma of the gums. Anatomo-clinical study of a case].

A case of malignant fibrous histiocytoma occurring in the gingival tissue on the site of the mandibular right canine is reported. The histological, histochemical, immunohistochemical and ultrastructural features are discussed and compared with the recent literature on malignant fibrous histiocytomas.

Metastatic atypical fibroxanthoma of skin.

Metastases from an atypical fibroxanthoma of skin have been reported but are very few in the literature. We had a personal case which, originally localized on the nostril, gave metastases to the cervical regional lymph node with no local recurrence. We examined both the primary and metastatic tumor by conventional histological stains and by immunoperoxidase technique to localize lysozyme, alpha-1-antitrypsin, ferritin and factor VIII antigens.

Hypokalemic myopathy in pseudohyperaldosteronism induced by fluoroprednisolone-containing nasal spray.

A man who was using 9-alpha-fluoroprednisolone-containing nasal spray preparation for allergic rhinitis developed a pseudohyperaldosteronism and an acute hypokalemic myopathy. Muscle biopsy changes included variation in fiber size with preserved type 2a fibers, necrosis, phagocytosis and regeneration. This factitious mineralocorticoid excess syndrome, induced by uncontrolled use of intranasally administered steroid, should be considered among the various causes of hypokalemic myopathy.

Fibrohistiocytic tumors of soft tissues. An immunohistochemical study of 183 cases.

183 cases of soft tissue tumors were studied utilizing the immunoperoxidase technique to demonstrate alpha-1-antitrypsin, ferritin and lysozyme. The series comprises 50 malignant lesions, 34 intermediate malignancy lesions, 99 benign lesions of fibrohistiocytic origin, and 23 malignant tumors of non fibrohistiocytic origin. The actual results of the study are as follows: alpha-1-antitrypsin, ferritin and lysozyme were always absent in 10 fibrosarcomas, 2 liposarcomas, 2 Ewing sarcomas, 3 synovial sarcomas, 4 neurofibrosarcomas, and 2 rhabdomyosarcomas, but in 24 malignant fibrous histiocytomas, 34 cases of dermatofibrosarcoma protuberans and 102 benign fibrohistiocytic lesions, these activities were present in a percentage that ranged between 12% and 38% (average 25%).

[Histological and ultrastructural studies on liver of rats treated with tiadenol].

By hystological and electronmicroscopical study liver of rats treated with tiadenol at a daily dose of 100 and 200 mg for 30 days, we could demonstrate: lack of necrosis and interstitial phlogosis and, especially in those animals treated with greater doses, numerical increase of peroxisomes, hypertrophy of SER and RER and a lesser regularity of glycogen distribution.

Response of rat hepatic fatty acid synthesis and activities of related enzymes to changes in level of dietary fat.

The rate of in vivo fatty acid synthesis as well as the levels of glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), malic enzyme (ME), citrate cleavage enzyme (CCE), acetyl-CoA carboxylase (ACX) and fatty acid synthetase (FAS) activities, have been studied in the liver of rats fed a fat-free diet for 7 days, followed by diets containing different amounts of soybean oil (0 to 24.79 kcal%) for 7 days. The dietary fat depressed activities of G6PD, 6PGD, ME, CCE, and FAS significantly at 1.