Does Low Back Pain Improve Following Total Hip Arthroplasty?

Background: Frequently, patients indicated for total hip arthroplasty (THA) present with low back pain (LBP) and hip pain. The purpose of this study was to compare patients whose back pain resolved after THA with those where back pain did not resolve and identify how to predict this using spinopelvic parameters.

Methods: We reviewed a series of 500 patients who underwent THA for unilateral hip osteoarthritis by 2 surgeons.

"You're going to look at me differently": A qualitative study of disclosure experiences among survivors of military sexual assault.

Most survivors of sexual assault who disclose their experience do so within their social network. Prior research on disclosure among individuals who experience sexual trauma has mainly focused on childhood sexual abuse, college-aged women, or disclosure to formal sources of support (e.g.

Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex.

Fine particulate matter (PM) potentiates in utero oxidative stress influencing fetal development while antioxidants have potential protective effects. We examined associations among prenatal PM, maternal antioxidant intake, and childhood wheeze in an urban pregnancy cohort ( = 530). Daily PM exposure over gestation was estimated using a satellite-based spatiotemporally resolved model.

Dogs ≥ five years of age at the time of congenital extrahepatic portosystemic shunt diagnosis have better long-term outcomes with surgical attenuation than with medical management alone.

Objective: To determine the outcome in dogs diagnosed with congenital extrahepatic portosystemic shunts (EHPSS) at ≥ 5 years of age treated with medical management only (M) or with surgical attenuation (S). The hypothesis was that dogs undergoing surgical attenuation would have a longer survival time than dogs undergoing medical management only.

Animals: 351 dogs definitively diagnosed with EHPSS at ≥ 5 years of age.

Comparing the use of mathematical calculation to a measuring wheel to determine distance walked in three different course configurations of the 6 minute Walk Test in healthy adults.

Introduction: A recent clinical practice guideline set forth recommendations for the administration of the 6 Minute Walk Test, including course set-up and using mathematical calculation to obtain the distance walked. In clinical practice and research, however, deviations from these protocols exist.

Purpose: To assess for differences in total distance walked between use of mathematical calculation and a measuring wheel during three different course configurations of the 6 Minute Walk Test.

Characterization of produced water and surrounding surface water in the Permian Basin, the United States.

A thorough understanding of produced water (PW) quality is critical to advance the knowledge and tools for effective PW management, treatment, risk assessment, and feasibility for beneficial reuse outside the oil and gas industry. This study provides the first step to better understand PW quality to develop beneficial reuse programs that are protective of human health and the environment. In total, 46 PW samples from unconventional operations in the Permian Basin and ten surface water samples from the Pecos River in New Mexico were collected for quantitative target analyses of more than 300 constituents.

Clinical Utility of the Signal-to-Cutoff Ratio of Reactive HIV Antigen/Antibody Screening Tests in Guiding Emergency Physician Management.

Background: The signal-to-cutoff (S/CO) ratio of the HIV antigen/antibody test may help immediately to differentiate true-positive results from false-positive results, which may be particularly useful in time-sensitive circumstances, such as when providing emergency department (ED) care.

Setting: Seven US EDs with HIV screening programs using HIV antigen/antibody assays.

Methods: This cross-sectional study of existing data correlated S/CO ratios with confirmed HIV status.

A review identified challenges distinguishing primary reports of randomized trials for meta-research: A proposal for improved reporting.

Meta-research is the discipline of studying research itself. A core investigative tool in meta-research is the use of systematic or scoping reviews to study the characteristics, methods and reporting of primary research studies. In the context of identifying eligible publications for methodological reviews of randomized controlled trials (RCTs), a challenge is to efficiently distinguish the primary trial report - which reports results for the primary outcome - from other types of reports, including design papers and secondary or supplementary analyses, or what we collectively refer to as non-primary reports.

Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein.

The development of small-molecules targeting different components of SARS-CoV-2 is a key strategy to complement antibody-based treatments and vaccination campaigns in managing the COVID-19 pandemic. Here, we show that two thiol-based chemical probes that act as reducing agents, P2119 and P2165, inhibit infection by human coronaviruses, including SARS-CoV-2, and decrease the binding of spike glycoprotein to its receptor, the angiotensin-converting enzyme 2 (ACE2). Proteomics and reactive cysteine profiling link the antiviral activity to the reduction of key disulfides, specifically by disruption of the Cys379-Cys432 and Cys391-Cys525 pairs distal to the receptor binding motif in the receptor binding domain (RBD) of the spike glycoprotein.

Early ambulation after transfemoral diagnostic cerebral angiography: a pilot study.

Background: A significant proportion of transfemoral cerebral angiography complications are related to the access site, with no clear consensus concerning the optimal closure technique. In this study, we examined the usefulness of a shortened closure protocol for transfemoral diagnostic cerebral angiography.

Methods: We performed a retrospective review of patients who underwent transfemoral (4Fr sheath) diagnostic cerebral angiography procedures at our institution.

Racial/ethnic and neighborhood disparities in metals exposure during pregnancy in the Northeastern United States.

Despite the unequal burden of environmental exposures borne by racially minoritized communities, these groups are often underrepresented in public health research. Here, we examined racial/ethnic disparities in exposure to metals among a multi-ethnic sample of pregnant women. The sample included women enrolled in the PRogramming of Intergenerational Stress Mechanisms (PRISM) pregnancy cohort (N = 382).

A Cascaded Droplet Microfluidic Platform Enables High-Throughput Single Cell Antibiotic Susceptibility Testing at Scale.

The global threat of antibiotic resistance underscores critical but unmet needs for rapid antibiotic susceptibility testing (AST) technologies. To this end, droplet microfluidic-based single-cell AST offers promise by achieving unprecedented rapidity, but its potential for clinical use is marred by the capacity of testing one to few antibiotic conditions per device, which falls short from the required scale in clinically relevant scenarios. To lift the scalability constraint in rapid single-cell AST technologies, a new cascaded droplet microfluidic platform that can streamline bacteria/antibiotic mixing, single-cell encapsulation within picoliter droplets, incubation, and detection in a continuous, assembly-line-like workflow is developed.

The CALCIPHYX study: a randomized, double-blind, placebo-controlled, Phase 3 clinical trial of SNF472 for the treatment of calciphylaxis.

Background: Calcific uraemic arteriolopathy (CUA; calciphylaxis) is a rare disease seen predominantly in patients receiving dialysis. Calciphylaxis is characterized by poorly healing or non-healing wounds, and is associated with mortality, substantial morbidity related to infection and typically severe pain. In an open-label Phase 2 clinical trial, SNF472, a selective inhibitor of vascular calcification, was well-tolerated and associated with improvement in wound healing, reduction of wound-related pain and improvement in wound-related quality of life (QoL).

Toxicological characterization of produced water from the Permian Basin.

Produced water (PW) is a hypersaline waste stream generated from the shale oil and gas industry, consisting of numerous anthropogenic and geogenic compounds. Despite prior geochemical characterization, the comprehensive toxicity assessment is lacking for evaluating treatment technologies and the beneficial use of PW. In this study, a suite of in vitro toxicity assays using various aquatic organisms (luminescent bacterium Vibrio fischeri, fish gill cell line RTgill-W1, and microalgae Scenedesmus obliquus) were developed to investigate the toxicological characterizations of PW from the Permian Basin.

Fertility care expectations: what do PLHIV and health care providers in Jamaica know about assisted reproduction services for safe conception?

Increased life expectancy among persons living with HIV (PLHIV) has increased the desire for parenthood. It is therefore important that PLHIV and health care providers (HCPs) are aware of the available assisted reproduction services (ARS) for PLHIV facing infertility or unsuppressed viremia. Through secondary data analysis we identified PLHIV who were actively trying to conceive and their knowledge of ARS.

Anterior Cruciate Ligament Reconstruction Using Bone-Patellar Tendon-Bone Allograft in Patients Aged 50 and Older Leads to Improved Activity Levels and Acceptable Patient-Reported Outcomes.

Purpose: To evaluate patient-reported outcomes in patients aged 50 years and older undergoing anterior cruciate ligament reconstruction (ACLR) using bone-patellar tendon-bone (BPTB) allograft with minimum 2-year follow-up.

Methods: A retrospective review was performed on a consecutive series of patients aged 50 and older who underwent ACLR using BPTB allograft by a single surgeon with minimum 2-year follow-up. Postoperative International Knee Documentation Committee (IKDC), Lysholm, and Physical Component Summary of the 12-item Short-Form Health Survey were used to assess outcomes, as well as preoperative and postoperative Tegner activity scores, which were compared using a paired sample test.

The effects of wireless devices on male reproductive health: A literature overview.

Purpose: The aim of this study was to summarize the evidence of radiofrequency electromagnetic radiation (RF-EMR) exposure from wireless devices on total motile sperm count (TMSC) and identify gaps in the literature that could help clarify this link.

Materials And Methods: A literature search was conducted using PubMed/MEDLINE to find relevant studies examining the effects of EMR on male fertility, with a specific focus on TMSC, published from 2000 to 2019. R was used for data analyses.

Metaphorically Speaking: Living the Art of Nursing and Meaningful Insights.

The importance of honoring and attending to human expressions, including metaphor, is more than an exercise in rhetorical flourish. Attending to metaphorical expressions is an inherent whole-in-motion connection of living the art of humanbecoming with the attention to honoring personal values and choices. The humanbecoming paradigm offers a person-centered approach and thus advances the trust of persons within the various communities receiving healthcare.

Prenatal PM exposure and infant temperament at age 6 months: Sensitive windows and sex-specific associations.

Background: Prenatal exposure to fine particulate matter with a diameter of ≤2.5 μm (PM) has been linked to adverse neurodevelopmental outcomes in later childhood, while research on early infant behavior remains sparse.

Objectives: We examined associations between prenatal PM exposure and infant negative affectivity, a stable temperamental trait associated with longer-term behavioral and mental health outcomes.

Review of pragmatic trials found that multiple primary outcomes are common but so too are discrepancies between protocols and final reports.

Objectives: To describe prevalence of multiple primary outcomes, changes in primary outcomes and target sample sizes between protocols and final reports, and how issues of multiplicity are addressed in pragmatic trials.

Study Design And Setting: Individually randomized trials labeled as pragmatic, published 2014-2019 in MEDLINE and registered with ClinicalTrials.gov.

Outcome of Gastrocnemius Soleus Facial Lengthening in Ambulatory Patients With Cerebral Palsy.

Background: Treatment of equinus contractures in children with cerebral palsy (CP) varies across centers. Existing literature utilizes mixed study populations with a variety of procedures. As such, there is limited knowledge regarding recurrence rates and efficacy of a single procedure performed on a homogenous cohort.

Methodological challenges in pragmatic trials in Alzheimer's disease and related dementias: Opportunities for improvement.

Background And Aims: We need more pragmatic trials of interventions to improve care and outcomes for people living with Alzheimer's disease and related dementias. However, these trials present unique methodological challenges in their design, analysis, and reporting-often, due to the presence of one or more sources of clustering. Failure to account for clustering in the design and analysis can lead to increased risks of Type I and Type II errors.

Systematic prioritization protocol applied to wolverine habitat connectivity.

I describe a prioritization protocol for future wolverine habitat connectivity conservation using integer linear programming. Conservation prioritization has broad applications across scales, systems, and species. However, the process of preparing, generating, and analyzing the necessary data can be complex.