Publications by authors named "Carrier M"
Trauma is an established risk factor for venous thromboembolism (VTE). Whether minor trauma is linked to greater risk of VTE remains unclear given that many studies evaluating trauma and VTE risk have not differentiated risk by trauma severity. Furthermore, the underlying risk of VTE is not uniform across all injured patients.
View Article and Find Full Text PDFBackground: Risk of VTE recurrence (VTEr) in patients with cancer-associated thrombosis (CAT) is high. Cancer-related risk factors for VTEr have been studied, but information about the importance of location of metastasis is scarce.
Objectives: 1) Evaluate rate of VTEr in CAT patients according to location of metastasis, and 2) Identify variables associated to VTEr during long-term follow-up.
Introduction: Outpatient management of pulmonary embolism (PE) remains controversial in patients with cancer due to their higher risks of mortality, recurrent venous thromboembolism (VTE) and bleeding complications. This systematic review and meta-analysis aimed to evaluate the safety and feasibility of outpatient management of cancer-associated PE.
Methods: We searched MEDLINE, Embase, Cochrane Central, and Scopus databases from inception to May 30, 2024, for studies on outpatient management of cancer-associated PE.
Both the incidence and prognosis of arterial atherothrombosis and venous thromboembolism are strongly correlated with increasing age. Over the past decade, clonal hematopoiesis of indeterminate potential (CHIP) has been identified as a novel biomarker for cardiovascular disease. Driven by somatic mutations in the hematopoietic system, the epidemiology of CHIP is highly age-dependent: among individuals aged ≥70 years in the general population, estimated prevalence of CHIP exceeds 10%.
View Article and Find Full Text PDFArticle Synopsis
- Limited research on oral health in systemic sclerosis prompts a scoping review to identify studies related to quality of life across five key domains: symptoms, functional impacts, psychosocial factors, patient-related variables, and self-care practices.
- From 1460 studies reviewed, only 91 were included, with most being conducted in Europe or North America and featuring small participant numbers, indicating a significant gap in comprehensive research.
- The majority of studies focus on oral manifestations and symptoms, with fewer addressing other crucial areas; further systematic reviews and larger studies are essential to improve understanding and care for systemic sclerosis patients.
Introduction/objective: The Scleroderma Patient-centered Intervention Network Support group Leader EDucation Program was found in a randomized controlled trial to substantially improve leader self-efficacy. Whether the program is effective for leaders with different levels of experience, including candidate leaders with no prior experience and leaders with ⩽3 years experience or ⩾4 years experience, is not known. The objective of the present post hoc secondary analysis was to evaluate outcomes by leader experience, age, and education.
View Article and Find Full Text PDFCoronary artery disease (CAD) is more prevalent in men than in women, with endothelial dysfunction, prodromal to CAD, developing a decade earlier in middle-aged men. We investigated the molecular basis of this dimorphism ex vivo in arterial segments discarded during surgery of CAD patients. The results reveal a lower endothelial relaxant sensitivity in men, and a senescence-associated inflammaging transcriptomic signature in endothelial cells.
View Article and Find Full Text PDFBackground: Heart donation (HD) by those with death determination by circulatory criteria (DDCC) has been proposed as a method to increase the heart donor pool in response to the growing need for heart transplantation (HT). However, the potential level of HD after DDCC in the province of Québec has not yet been reported. This study aims to assess the suitability for HD among donors with DDCC, and to estimate its impact on HT activity.
View Article and Find Full Text PDFDéjà vu all over again: a recurrent flaw in anticoagulant study design.
J Thromb Haemost
October 2024
Article Synopsis
- The introduction of direct oral anticoagulants (DOACs) since 2010 has significantly changed blood-thinning treatments, shown to be effective and often safer than warfarin for patients of all ages.
- Postmarketing data revealed a higher incidence of heavy menstrual bleeding (HMB) with rivaroxaban, an issue that wasn't evident during clinical trials.
- Current research is exploring Factor XI inhibitors as a new anticoagulant option, but a systematic review found a lack of studies focusing on menstruating individuals and uterine bleeding, indicating a gap in clinical trial designs.
Article Synopsis
- A study compared fatigue levels in a large group of people with systemic sclerosis (SSc) to typical fatigue levels in the general population, finding that SSc patients experienced significantly more fatigue.
- Participants included 2,385 individuals, with a majority being female and averaging around 55 years old, and it was noted that 18% reported mild fatigue, 27% moderate fatigue, and 8% severe fatigue.
- Factors such as age, gender, marital status, fatigue-related lifestyle choices (like smoking and BMI), and specific disease features (like gastrointestinal issues and joint problems) were all linked to higher fatigue scores in SSc patients.
Background: Limited language proficiency is an established barrier to research participation among racialized populations. While prior studies have highlighted the underrepresentation of racialized populations in venous thromboembolism (VTE) research, the impact of limited language proficiency as a reason for nonconsent among eligible patients is unknown.
Objectives: To determine the impact of language barrier as the primary reason for VTE research non-participation.
Article Synopsis
- After 3 months of anticoagulation treatment for venous thromboembolism (VTE), clinicians must decide on continuing or stopping the treatment, ideally guided by the VTE-PREDICT calculator that estimates risks of recurrence and bleeding.
- A study involved clinicians evaluating fictional VTE cases; some made duration proposals without calculator input (Group A), while others used the calculator to inform their decisions (Group B).
- Results showed no overall difference in proposed durations between the two groups, yet many in Group A adjusted their recommendations after seeing the calculator risks, noting its usefulness, particularly for patients at high bleeding risk.
Article Synopsis
- - Abiraterone acetate, apalutamide, darolutamide, and enzalutamide are androgen receptor axis-targeted therapies (ARATs) used to treat prostate cancer, often alongside oral antithrombotic therapies, which may lead to significant drug-drug interactions.
- - A multidisciplinary expert panel used a modified electronic Delphi process to reach consensus on which ARAT/antithrombotic pairs should be monitored and how to manage these interactions, ultimately recommending avoiding 11 pairs and modifying therapy for 8 others.
- - This process underscores the need for more research into the clinical outcomes of ARAT and antithrombotic interactions while providing clinicians with actionable guidance for safer therapeutic choices. *
Background: Tumor thrombus can be associated with an increased risk of venous thromboembolism (VTE) and poor prognosis. The risks and benefits of anticoagulation remain unclear.
Objectives: To evaluate the role of anticoagulation and associated outcomes in patients with tumor thrombus.
Article Synopsis
- The study examined changes in work status, financial adequacy, and preferences for remote versus in-office work among individuals with systemic sclerosis during the COVID-19 pandemic.
- Conducted with 298 participants, findings revealed that most people's work status and financial well-being remained stable from April 2020 to August 2022, with only a few changes in employment.
- Participants preferred flexible work arrangements, but most were required to work in a fixed, in-person setting, suggesting a need for more adaptable workplace policies to accommodate their conditions.
Introduction: Factor Xa inhibitor (FXaI)-associated bleeding events are common and associated with substantial morbidity. Systematic evaluation of widely available, effective, and affordable FXaI bleed management strategies is needed.
Materials And Methods: We conducted a single-center retrospective cohort study of FXaI-treated patients presenting to a tertiary academic medical center from January 2018 to May 2019 who received 25-50 IU/kg 4F-PCC for either FXaI-associated major bleeding or urgent surgery.
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphoma localized to the central nervous system. Small single-center studies have suggested that patients with PCNSL may be at high risk of venous thromboembolism (VTE). This systematic review aimed to estimate the risk of VTE in patients with PCNSL.
View Article and Find Full Text PDFAims: Incidence of arterial thromboembolism (ATE) among ambulatory cancer patients varies by primary tumor site. However, it is unclear whether this alters the benefit-to-harm profile of prophylactic anticoagulation for ATE prevention. Therefore, we systematically evaluated the efficacy and safety of anticoagulants for ATE prevention among ambulatory cancer patients according to the primary tumor site.
View Article and Find Full Text PDFBackground: Raynaud's phenomenon is the earliest and most common systemic sclerosis manifestation. Episodes can be triggered by cold exposure and ambient temperature changes. Small studies have found that Raynaud's phenomenon outcomes were associated with season.
View Article and Find Full Text PDFBackground: Use of extended pharmacologic thromboprophylaxis after major abdominopelvic cancer surgery should depend on best-available scientific evidence and patients' informed preferences. We developed a risk-stratified patient decision aid to facilitate shared decision-making and sought to evaluate its effect on decision-making quality regarding use of extended thromboprophylaxis.
Methods: We enrolled patients undergoing major abdominopelvic cancer surgery at an academic tertiary care centre in this pre-post study.
Cancer-associated venous thromboembolism (CAT) is common in patients with cancer and associated with significant morbidity and mortality. The incidence of CAT continues to rise, complicating patient care and burdening healthcare systems. Patients with cancer experiencing VTE face poorer prognoses, making prevention and effective management imperative.
View Article and Find Full Text PDF