Publications by authors named "Carrie Leung"
Article Synopsis
- Researchers used plasmid DNA vaccines targeting specific cancer markers (melanosomal differentiation antigens) to stimulate immune responses against melanoma in mice, leading to the exploration of this approach in dogs.
- In a Phase I clinical trial, nine dogs with advanced melanoma received a human tyrosinase DNA vaccine, showing safety and a longer survival compared to historical controls.
- Three dogs developed antibodies specific to tyrosinase, indicating the vaccine's potential to overcome the dog's immune tolerance to its own proteins, which may correlate with their improved tumor control and survival rates.
