Publications by authors named "Carrie Jiaxin Li"
Article Synopsis
- Zinc-finger nucleases (ZFNs) are used for precise genome editing by creating double-strand breaks (DSBs), leading to targeted gene disruptions or additions through specific DNA repair pathways.
- Researchers have engineered ZFNs to create single-strand breaks (SSBs), which promote gene addition without significantly causing small insertions or deletions typical of DSB repair via nonhomologous end-joining (NHEJ).
- The study demonstrates that SSBs can enhance gene addition efficiency in human cells and suggests that using SSBs may help direct repair pathways beneficial for treating genetic disorders.
