Publications by authors named "Carrie E Barnum"
Appropriate timing of cervical remodeling (CR) is key to normal term parturition. To date, mechanisms behind normal and abnormal (premature or delayed) CR remain unclear. Recent studies show regional differences exist in human cervical tissue structure.
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- - The study investigates the role of Tdrd7 protein mutations in early onset cataracts by examining a knockout mouse model, focusing on how these mutations affect microRNA (miRNA) expression and contribute to cataract formation.
- - Researchers identified 22 significantly misexpressed miRNAs in the lenses of mice before cataract development, with 14 miRNAs being over-expressed and 8 being reduced, suggesting a complex regulatory network affected by Tdrd7 deficiency.
- - Comparative transcriptomics analysis revealed 98 reduced and 89 elevated mRNA targets linked to the misexpressed miRNAs, which were classified based on their potential impact on lens biology and pathology, indicating their significance in cataract development.
Mutations of the RNA granule component TDRD7 (OMIM: 611258) cause pediatric cataract. We applied an integrated approach to uncover the molecular pathology of cataract in Tdrd7-/- mice. Early postnatal Tdrd7-/- animals precipitously develop cataract suggesting a global-level breakdown/misregulation of key cellular processes.
View Article and Find Full Text PDFThe role of the cervicovaginal (CV) microbiome in regulating cervical function during pregnancy is poorly understood. Gardnerella vaginalis (G. vaginalis) is the most common bacteria associated with the diagnosis of bacterial vaginosis (BV).
View Article and Find Full Text PDFThe small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of collagen fibril and matrix assembly. The goal of this work was to elucidate the roles of decorin and biglycan in tendon homeostasis. Our central hypothesis is that decorin and biglycan expression in the mature tendon would be critical for the maintenance of the structural and mechanical properties of healthy tendons.
View Article and Find Full Text PDFThe cervix is a unique organ able to dramatically change its shape and function by serving as a physical barrier for the growing fetus and then undergoing dramatic dilation allowing for delivery of a term infant. As a result, the cervix endures changing mechanical forces from the growing fetus. There is an emerging concept that the cervix may change or remodel "early" in many cases of spontaneous preterm birth (sPTB).
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- * Research on RNA-binding proteins (RBPs) reveals that around 60% of RBPs linked to vertebrate eye development are associated with RNA granules, suggesting their crucial role in posttranscriptional regulation during eye morphogenesis.
- * Evidence connecting specific RBPs, like Tdrd7, Caprin2, and Stau2, to eye developmental defects implies the need for further investigation, using tools like iSyTE, to understand the posttranscriptional regulatory networks at play in eye development and associated diseases.