Assessment and management of cutaneous reactions with amifostine administration: findings of the ethyol (amifostine) cutaneous treatment advisory panel (ECTAP).

Purpose: To review reports of severe skin reactions during amifostine treatment.

Methods And Material: The expert panel reviewed postmarketing reports of skin reactions and discussed strategies for evaluation and management.

Results: Between 1994 and April 2002, 35 events were classified as severe skin reactions worldwide: erythema multiforme (8), Stevens-Johnson syndrome (10), toxic epidermal necrolysis (11), toxicoderma (3), and bullae (3).