Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G.

Background: To our knowledge, there is no useful and accurate prognostic biomarker or biomarkers for patients with oral squamous cell carcinoma (OSCC), a tumor with uncertain biological behavior, and unpredictable clinical progress. The purposes of this study were: a) to determine the expresión profile of Connexin 43, Bcl-2, Bax, E-cadherin, and Ki67 in patients with OSCC; b) identify the GJCA1 rs12197797 genotypic composition.

Material And Methods: A cross-sectional study using genomic DNA and biopsy samples extracted from the oral mucosa with/without OSCC, older than 18 years, both genders, attended at Facultad de Odontología, Universidad Nacional Córdoba.

DNA repair, NFKβ, and TP53 polymorphisms associated with potentially malignant disorders and oral squamous cell carcinoma in Argentine patients.

Objective: An important strategy in cancer prevention is to identify individual susceptibilities for cancer development through the genomic profile. Developing countries such as Argentina have no data on genetic composition. The aim of this study was to evaluate the single nucleotide polymorphisms of genes related to DNA repair (XCCR3, XPD), cell cycle arrest/apoptosis (TP53), and inflammation (NFKβ) of patients with precancer and oral cancer and to contribute to recognizing potential risk of developing these pathologies, and incorporate the risk patients into a clinical follow-up program in Córdoba, Argentina.

Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients.

The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR.

Exfoliative cytology as a tool for monitoring pre-malignant and malignant lesions based on combined stains and morphometry techniques.

Background: Prevention and early diagnosis have the greatest potential for public health and are the most effective method in the long-term to control oral cancer. The aim was to apply PAP staining together with AgNOR staining and morphometric analysis in oral exfoliative cytology, to determine the sensitivity and specificity of these methods in the detection of malignant changes for the purposes of both initial population monitoring and follow-up.

Methods: AgNOR, Papanicolau, and morphometric tests were conducted in samples of patients with oral cancer, oral potentially malignant disorders and controls (opposite side of lesions).

[A case of retinitis in a patient with schistosomiasis (author's transl)].

The authors report a case of pure macular oedema. After ruling out all other etiologies, the diagnosis of schistosomiasis due to Schistosoma mansoni was established, with parasitologic and serologic proofs. The specific treatment was followed up by a progressive restoration associated with an acute increase of eosinophila.

[Retinopathy due to amino-4-quinoleines group of the synthetic antimalarial drugs (author's transl)].

The use of overdoses of amino-4-quinoleines in non-malarial diseases has demonstrated various toxic actions on eyes. The most severe is retina lesion. Metabolism of these drugs and pathogeny of the lesions are discussed.

[Ocular lesions in leprosy (author's transl)].

Modern authors estimate from 47 p. 100 to 78 p. 100 the frequency of ocular lesions in leprosy.

[Wide angle chronic glaucoma in Negroes (author's transl)].

A review of the question of primitive wide angle chronic glaucoma in Negroes. Its frequency, early apparition, frequent unilateral localization and poor improvement with medical treatment are emphasized. The present trends in surgical procedures are given.

[Drepanocytic retinopathy (author's transl)].

Hemoglobinopathies and specially drepanocytosis SS and its heterozygotic form SC are responsible of important pathological changes of retina. These changes caused by ischaemia due to vascular thrombosis are generally silent at their beginning, because of their first development in a peripheral area. They have a tendency to progress towards the posterior pole and to get complicated by hemorrhages and detachment of retina.