Are the early stages of orthographic processing universal? Insights from masked priming with Semitic words.

Two views contend to account for the processes at play during the early stages of visual word recognition. The first holds that these stages are not modulated by the idiosyncratic properties of different languages. The second maintains that the structural properties of the language determine the weighting of the different domains of linguistic knowledge (e.

Unveiling the neuroplastic capacity of the bilingual brain: insights from healthy and pathological individuals.

Research on the neural imprint of dual-language experience, crucial for understanding how the brain processes dominant and non-dominant languages, remains inconclusive. Conflicting evidence suggests either similarity or distinction in neural processing, with implications for bilingual patients with brain tumors. Preserving dual-language functions after surgery requires considering pre-diagnosis neuroplastic changes.

Hydrazides as Inhibitors of Histone Deacetylases.

In this Perspective, we have brought together available biological evidence on hydrazides as histone deacetylase inhibitors (HDACis) and as a distinct type of Zn-binding group (ZBG) to be reviewed for the first time in the literature. -Alkyl hydrazides have transformed the field, providing innovative and practical chemical tools for selective and effective inhibition of specific histone deacetylase (HDAC) enzymes, in addition to the usual hydroxamic acid and -aminoanilide ZBG-bearing HDACis. This has enabled efficient targeting of neurodegenerative diseases such as Alzheimer's disease, cancer, cardiovascular diseases, and protozoal pathologies.

Switching off: disruptive TMS reveals distinct contributions of the posterior middle temporal gyrus and angular gyrus to bilingual speech production.

The role of the left temporoparietal cortex in speech production has been extensively studied during native language processing, proving crucial in controlled lexico-semantic retrieval under varying cognitive demands. Yet, its role in bilinguals, fluent in both native and second languages, remains poorly understood. Here, we employed continuous theta burst stimulation to disrupt neural activity in the left posterior middle-temporal gyrus (pMTG) and angular gyrus (AG) while Italian-Friulian bilinguals performed a cued picture-naming task.

Decoding bilingualism from resting-state oscillatory network organization.

Can lifelong bilingualism be robustly decoded from intrinsic brain connectivity? Can we determine, using a spectrally resolved approach, the oscillatory networks that better predict dual-language experience? We recorded resting-state magnetoencephalographic activity in highly proficient Spanish-Basque bilinguals and Spanish monolinguals, calculated functional connectivity at canonical frequency bands, and derived topological network properties using graph analysis. These features were fed into a machine learning classifier to establish how robustly they discriminated between the groups. The model showed excellent classification (AUC: 0.

Early language dissociation in bilingual minds: magnetoencephalography evidence through a machine learning approach.

Does neural activity reveal how balanced bilinguals choose languages? Despite using diverse neuroimaging techniques, prior studies haven't provided a definitive solution to this problem. Nonetheless, studies involving direct brain stimulation in bilinguals have identified distinct brain regions associated with language production in different languages. In this magnetoencephalography study with 45 proficient Spanish-Basque bilinguals, we investigated language selection during covert picture naming and word reading tasks.

Does bilingual experience influence statistical language learning?

Statistical language learning (SL) tasks measure different aspects of foreign language learning. Studies have used SL tasks to investigate whether bilingual experience confers advantages in acquiring additional languages through implicit processes. However, the results have been inconsistent, which may be related to bilingualism-related features (e.

Word frequency and reading demands modulate brain activation in the inferior frontal gyrus.

Processing efficiency differs between high- and low-frequency words, with less frequent words resulting in longer response latencies in several linguistic behavioral tasks. Nevertheless, studies using functional MRI to investigate the word frequency effect have employed diverse methodologies and produced heterogeneous results. In this study, we examine the effect of word frequency through complementary analytical approaches and functional connectivity analyses.

A novel cognitive neurosurgery approach for supramaximal resection of non-dominant precuneal gliomas: a case report.

Despite mounting evidence pointing to the contrary, classical neurosurgery presumes many cerebral regions are non-eloquent, and therefore, their excision is possible and safe. This is the case of the precuneus and posterior cingulate, two interacting hubs engaged during various cognitive functions, including reflective self-awareness; visuospatial and sensorimotor processing; and processing social cues. This inseparable duo ensures the cortico-subcortical connectivity that underlies these processes.

Decoding numeracy and literacy in the human brain: insights from MEG and MVPA.

Numbers and letters are the fundamental building blocks of our everyday social interactions. Previous studies have focused on determining the cortical pathways shaped by numeracy and literacy in the human brain, partially supporting the hypothesis of distinct perceptual neural circuits involved in the visual processing of the two categories. In this study, we aim to investigate the temporal dynamics for number and letter processing.

Cognitive reserve counteracts typical neural activity changes related to ageing.

Studies have shown that older adults with high Cognitive Reserve (HCR) exhibit better executive functioning than their low CR (LCR) counterparts. However, the neural processes linked to those differences are unclear. This study investigates (1) the neural processes underlying executive functions in older adults with HCR compared to older adults with LCR and (2) how executive control differences between HCR and LCR groups are modulated by increased task difficulty.

Behavioral and oscillatory signatures of switch costs in highly proficient bilinguals.

Bilinguals with a high proficiency in their first (L1) and second language (L2) often show comparable reaction times when switching from their L1 to L2 and vice-versa ("symmetrical switch costs"). However, the neurophysiological signatures supporting this effect are not well understood. Here, we ran two separate experiments and assessed behavioral and MEG responses in highly proficient Spanish-Basque bilinguals while they overtly name pictures in a mixed-language context.

Morphological decomposition in Chinese compound word recognition: Electrophysiological evidence.

The present study examined the effect of both morphological complexity and semantic transparency in Chinese compound word recognition. Using a visual lexical decision task, our electrophysiological results showed that transparent and opaque compounds induced stronger Left Anterior Negativity (LAN) than monomorphemic words. This result suggests that Chinese compounds might be decomposed into their constituent morphemes at the lemma level, whereas monomorphemic words are accessed as a whole-word lemma directly from the form level.

Brain structure, phenotypic and genetic correlates of reading performance.

Reading is an evolutionarily recent development that recruits and tunes brain circuitry connecting primary- and language-processing regions. We investigated whether metrics of the brain's physical structure correlate with reading performance and whether genetic variants affect this relationship. To this aim, we used the Adolescent Brain Cognitive Development dataset (n = 9,013) of 9-10-year-olds and focused on 150 measures of cortical surface area (CSA) and thickness.

Theta-gamma phase-amplitude coupling in auditory cortex is modulated by language proficiency.

The coordination between the theta phase (3-7 Hz) and gamma power (25-35 Hz) oscillations (namely theta-gamma phase-amplitude coupling, PAC) in the auditory cortex has been proposed as an essential neural mechanism involved in speech processing. However, it has not been established how this mechanism is related to the efficiency with which a listener processes speech. Speech processing in a non-native language offers a useful opportunity to evaluate if theta-gamma PAC is modulated by the challenges imposed by the reception of speech input in a non-native language.

"Neural dynamics supporting longitudinal plasticity of action naming across languages: MEG evidence from bilingual brain tumor patients".

Previous evidence suggests that distinct ventral and dorsal streams respectively underpin the semantic processing of object and action knowledge. Recently, we found that brain tumor patients with dorsal gliomas in frontoparietal hubs show a selective longitudinal compensation (post-vs. pre-surgery) during the retrieval of lexico-semantic information about actions (but not objects), indexed by power increases in beta rhythms (13-28 Hz).

Cross-modal and cross-language activation in bilinguals reveals lexical competition even when words or signs are unheard or unseen.

We exploit the phenomenon of cross-modal, cross-language activation to examine the dynamics of language processing. Previous within-language work showed that seeing a sign coactivates phonologically related signs, just as hearing a spoken word coactivates phonologically related words. In this study, we conducted a series of eye-tracking experiments using the visual world paradigm to investigate the time course of cross-language coactivation in hearing bimodal bilinguals (Spanish-Spanish Sign Language) and unimodal bilinguals (Spanish/Basque).

Open access dataset of task-free hemodynamic activity in 4-month-old infants during sleep using fNIRS.

Spontaneous, task-free, hemodynamic activity of the brain provides useful information about its functional organization, as it can describe how different brain regions communicate to each other. Neuroimaging studies measuring the spontaneous activity of the brain are conducted while the participants are not engaged in a particular task or receiving any external stimulation. This approach is particularly useful in developmental populations as brain activity can be measured without the need for infant compliance and the risks of data contamination due to motion artifacts.

Mind the orthography: Revisiting the contribution of prereading phonological awareness to reading acquisition.

Reading acquisition is based on a set of preliteracy skills that lay the foundation for future reading abilities. Phonological awareness-the ability to identify and manipulate the sound units of oral language-has been reported to play a central role in reading acquisition. However, current evidence is mixed with respect to its universal contribution to reading acquisition across orthographies.

Verbal production dynamics and plasticity: functional contributions of language and executive control systems.

Bilingual language production requires both language knowledge and language control in order to communicate in a target language. Learning or improving a language in adulthood is an increasingly common undertaking, and this has complex effects on the cognitive and neural processes underlying language production. The current functional magnetic resonance imaging (fMRI) experiment investigated the functional plasticity of verbal production in adult language learners, and examined the dynamics of word retrieval in order to dissociate the contributions of language knowledge and executive control.