Real-life management of patients with breakthrough cancer pain caused by bone metastases in Spain.

We aimed to explore the characteristics, and real-life therapeutic management of patients with breakthrough cancer pain (BTcP) caused by bone metastases in Spain, and to evaluate physicians' opinion of and satisfaction with prescribed BTcP therapy. For the purposes of this study, an ad-hoc questionnaire was developed consisting of two domains: a) organizational aspects and care standards; b) clinical and treatment variables of bone metastatic BTcP patients. In addition, physicians' satisfaction with their prescribed BTcP therapy was assessed.

Current management of breakthrough cancer pain according to physicians from pain units in Spain.

Purpose: Current evidence suggests the need to improve the management of breakthrough cancer pain (BTcP). For this reason, we aimed to assess the opinion of a panel of experts composed exclusively of physicians from pain units, who play a major role in BTcP diagnosis and treatment, regarding the key aspects of BTcP management.

Methods: An ad hoc questionnaire was developed to collect real-world data on the management of BTcP.

[Consensus statement on the use of acetaminophen/tramadol in patients with moderate-severe pain].

Objectives: To present recommendations on the use of the paracetamol/tramadol (P/T) combination in patients with moderate-intense pain based on best evidence and experience.

Methods: The method of nominal groups and Delphi was followed, and supported by a systematic literature review (SLR). A multidisciplinary panel of 12 experts in pain management was selected.

Docking-based virtual screening of Brazilian natural compounds using the OOMT as the pharmacological target database.

The demand for new therapies has encouraged the development of faster and cheaper methods of drug design. Considering the number of potential biological targets for new drugs, the docking-based virtual screening (DBVS) approach has occupied a prominent role among modern strategies for identifying new bioactive substances. Some tools have been developed to validate docking methodologies and identify false positives, such as the receiver operating characteristic (ROC) curve.

[Intraoperative control of mean arterial pressure and heart rate with alfentanyl with fuzzy logic].

Objectives: To describe a fuzzy logic controller that adjust alfentanil infusion during surgery based on changes in mean arterial pressure (MAP) and heart rate (HR).

Material And Methods: We designed a fuzzy logic controller using if ..

[Fuzzy logic and postoperative pain].

Objective: To apply a fuzzy logic expert control system for the treatment of postoperative pain in a clinical setting.

Material And Methods: A system was designed consisting of a perfusion pump guided by a fuzzy logic computer interface to regulate the perfusion of alfentanil in accordance with the patient's pain response. The system was also equipped with a safety device that halted perfusion in case of desaturation, bradypnea or heart rate or blood pressure variations greater than 25%.

[Design of an expert system for decision-making in an emergency situation].

Objectives: To study the clinical applicability of the expert system URGSANT as a help in making up decisions in emergencies.

Material And Methods: URGSANT is an expert system implemented in INSIGT 2+ which is structured in a modular and hierarchical form. It contemplates 44 urgent situations relating to the central nervous system, hematopoietic, cardiovascular, respiratory, gastrointestinal, genitourinary, endocrinological, and miscellaneous group.

[History of the introduction of ether anesthesia in Spain. A new contribution to its study].

Ether anesthesia was introduced in Spain on January 13, 1847. Dr. Diego de Argumosa y Obregón, from Madrid, was the first Spanish surgeon who operated with the help of sulphuric ether.