Aloe vera peel-derived nanovesicles display anti-inflammatory properties and prevent myofibroblast differentiation.

Background: Aloe vera (AV) is a medicinal plant, most known for its beneficial effects on a variety of skin conditions. Its known active compounds include carbohydrates and flavonoids such as quercetin and kaempferol, among others. In the past decade, plant nanovesicles (NVs) have gained considerable interest as interkingdom communicators, presenting an opportunity for clinical standardization of natural products.

Mitochondria in oral cancer stem cells: Unraveling the potential drug targets for new and old drugs.

Head and neck cancer is a major health problem worldwide, with most cases arising in the oral cavity. Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, accounting for over 90% of all cases. Compared to other types of cancer, OSCC, has the worse prognosis, with a 5-year survival rate of 50%.

[Impact of sperm morphology on pregnancy rates after intrauterine insemination].

Introduction And Objective: Sperm morphology has been used as a prognostic factor in in vitro fertilization, however, in intrauterine insemination (IUI) its predictive role is controversial. The aim of this study was to determine the impact of sperm morphology as isolated parameter of the spermiogram has on the probability of pregnancy in couples that are treated with IUI.

Material And Methods: Retrospective study of IUI cycles performed in the Reproductive Medicine Unit of Clínica Las Condes between January 2016 and December 2018.

Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin.

Cisplatin is a first-line chemotherapeutic drug commonly used to treat patients with head and neck cancer; nevertheless, cisplatin resistance poses a main challenge for its clinical efficacy. Recent studies have shown that kaempferol, a natural flavonoid found in various plants and foods, has an anticancer effect. The following study evaluated the cytotoxic effects of kaempferol on head and neck tumor cells and their mechanism of action, evaluating the effects on proliferation, the oxygen consumption rate, transmembrane potential, tumor cell migration and induction of apoptosis.

Acute dysphagia presentation and its association with esophagitis dissecans and concomitant diseases. A diagnostic challenge.

Esophagitis dissecans (ESD) is an uncommon disease that is associated with eosinophilic esophagitis (EoE), candidiasis and/or drugs. We aim to characterize the clinical, endoscopic and histological damage of the mucosal in subjects with dysphagia, its relation to concomitant entities and the treatment response. This is a retrospective observational study in patients with dysphagia and esophageal mucosal damage We included 23 patients (mean age = 55 years) who had GERD symptoms, dysphagia and/or odynophagia.

[Experiences of bullying in medical residents].

Background: Harassment and abuse are forms of persistent intimidating behavior against a person and in medical practice those are accepted and justified at all levels of education and are considered specific to the hospital culture.

Objective: To identify the frequency of harassment and some factors related to its existence on residents of medical specialties in Mexico City.

Method: A linear study was carried out in which a total of 260 interns pertaining to the following medical specialties: surgery, internal medicine, gynecology and obstetrics, and pediatrics participated.

The role of minimal invasive surgery in surgical education.

The first laparoscopic cholecystectomy carried out in 1985 generated a great enthusiasm about the new surgical technique; however, it was evident that educational techniques required improvement because this new procedure presented a higher prevalence of injuries in the biliary tract than conventional surgery. Minimally invasive surgery has a number of advantages over open surgery. Some of these advantages allowed the use of technology in order to generate experts, evaluate them objectively, document the process in video, assess their competence and use simulators to improve overall surgical education.

[Minimally invasive surgery of small intestine].

Since the first laparoscopic surgery was performed by Erick Mühe in 1986, multiple minimally invasive techniques have been developed. The small intestine presents several technical difficulties for the application of these techniques, namely: its size, mobilization inside the abdominal cavity, difficulty defining the site under manipulation and the distension association by an ileo or an occlusion. The development of new technology with better cameras and coagulation equipment such as the Harmonic Scalpel and the Ligasure, cutting linear staplers, have permitted the evolution of surgical techniques for the small intestine.