A potential explanation for the global increase in tropical cyclone rapid intensification.

Tropical cyclone rapid intensification events often cause destructive hurricane landfalls because they are associated with the strongest storms and forecasts with the highest errors. Multi-decade observational datasets of tropical cyclone behavior have recently enabled documentation of upward trends in tropical cyclone rapid intensification in several basins. However, a robust anthropogenic signal in global intensification trends and the physical drivers of intensification trends have yet to be identified.

Author Correction: Recent increases in tropical cyclone intensification rates.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

The Last Year Before Graft Failure Negatively Impacts Economic Outcomes and is Associated With Greater Healthcare Resource Utilization Compared With Previous Years in the United Kingdom: Results of a Retrospective Observational Study.

Background: Kidney and liver transplantation is the standard of care for end-stage renal or liver disease. However, long-term survival of kidney and liver grafts remain suboptimal. Our study aimed to understand the healthcare resources utilized and their associated costs in the years before graft failure.

Author Correction: Recent increases in tropical cyclone intensification rates.

The original version of this Article contained an error in the second sentence of the first paragraph of the 'Quantile mapping' section of the Methods, which incorrectly read 'We primarily focus on results produced using an additive version of QDM by making use of R programming language code contained in the CRAN MBC package version 0.10-438.' The correct version states 'QDM' in place of 'QDM'.

Recent increases in tropical cyclone intensification rates.

Tropical cyclones that rapidly intensify are typically associated with the highest forecast errors and cause a disproportionate amount of human and financial losses. Therefore, it is crucial to understand if, and why, there are observed upward trends in tropical cyclone intensification rates. Here, we utilize two observational datasets to calculate 24-hour wind speed changes over the period 1982-2009.

The UK patient experience of relapse in Multiple Sclerosis treated with first disease modifying therapies.

Background: The fixed, progressive disability associated with late Multiple Sclerosis (MS) is known to have a major impact on patients and their families, but the impact of relapse earlier in the disease course is less well documented, particularly from the patient׳s perspective. This study aimed to understand the effects of relapse for people with MS (PwMS), focussing on the years immediately after starting disease modifying therapy (DMT) when experience of a relapse may particularly influence a patient׳s opinions of their disease and its therapy.

Methods: This was a multi-centre, retrospective, observational research study, recruiting patients from 7 UK NHS Hospital Trusts.