Complex Medical Decision-Making for a Trans-Feminine Youth with a BRCA1 Mutation.

The risks of being a cisgender BRCA1/BRCA2 mutation carrier (BRCA1+/BRCA2+) are well documented, and recommendations to mitigate cancer risk in BRCA+ cisgender women are clear. However, there is a lack of guidance for BRCA+ transgender women. In this article, we discuss the case of a trans-feminine youth who presented at a gender clinic for medications for pubertal suppression and was identified as a BRCA1 mutation carrier.

A Transgender Woman with Testicular Cancer: A New Twist on an Old Problem.

We present the case of a transgender woman who developed rising testosterone and estradiol levels while on feminizing hormones. After months of uncertainty about the cause of her elevated hormone levels, her physician found a large testicular mass on examination. The patient was diagnosed with a rare virilizing form of testicular cancer.