Publications by authors named "Carolyn J Swann"
Article Synopsis
- - USP's peptide reference standards are usually assessed using HPLC assays against a purity standard determined by a mass balance method.
- - A collaborative study by the USP Biologics Department compared three quantitation methods (HPLC, qNMR, and AAA) for measuring oxytocin levels to evaluate inter-laboratory consistency.
- - Results showed HPLC had the least variability, but qNMR, being simpler and quicker, is suggested for more in-depth exploration as a primary method for peptide standard value assignment.
Polysaccharide (PS) based meningococcal vaccines are primarily evaluated by physicochemical methods to ensure batches are consistently manufactured. As PS content is determined by different methods across numerous laboratories, there is a need for International Standards (IS) to calibrate the assays. Following the successful introduction of the WHO Meningococcal group C (MenC) IS in 2011, NIBSC initiated projects to prepare similar standards for groups A, W, Y and X (MenA/W/Y/X) to standardise all meningococcal- PS based vaccines.
View Article and Find Full Text PDF