Publications by authors named "Carolyn Heckenmeyer"
Article Synopsis
- The study investigates the roles of hypoxia and hypoxia inducible factor (HIF) in chronic kidney disease (CKD), revealing that HIF activation and hypoxia levels do not significantly correlate in early stages of the disease.* -
- Findings show that while there is some hypoxia in late CKD stages, it does not coincide with fibrosis; instead, there is a notable increase in asparaginyl hydroxylase (FIH) expression linked to CKD severity.* -
- The research suggests that inhibiting FIH pharmacologically could improve kidney function and reduce fibrosis, questioning the previously assumed role of HIF in CKD progression.*
Introduction: CKD is associated with alterations of tubular function. Renal gluconeogenesis is responsible for 40% of systemic gluconeogenesis during fasting, but how and why CKD affects this process and the repercussions of such regulation are unknown.
Methods: We used data on the renal gluconeogenic pathway from more than 200 renal biopsies performed on CKD patients and from 43 kidney allograft patients, and studied three mouse models, of proteinuric CKD (POD-ATTAC), of ischemic CKD, and of unilateral urinary tract obstruction.
Article Synopsis
- NAD+ plays a crucial role in energy metabolism and is often deficient during acute kidney injury (AKI) and chronic kidney disease (CKD).
- The study examined NAD+ biosynthesis in human kidney biopsies and used mouse models to simulate AKI and CKD, investigating the effects of nicotinamide riboside (NR) supplementation.
- Results showed that NAD+ synthesis is impaired in AKI but NR supplementation helps in acute cases; however, it does not prevent progression in CKD models.