Publications by authors named "Carolyn H Rogers"
Article Synopsis
- The study focuses on the structural changes in immunoglobulin heavy-chain (Igh) loci that create diverse antibody repertoires, revealing the complexity of chromosomal interactions involved.
- Using a technique called tiled Capture Hi-C, researchers mapped chromatin interactions in the Igh locus of progenitor B cells, showing how the locus forms subdomains and flexible loops for gene recombination.
- They found that the unique structures of the Igh locus, along with interactions between different immunoglobulin loci and developmental factors, suggest a coordinated network that influences B cell development and antibody diversity.
Article Synopsis
- The text discusses how the adaptive immune system creates a diverse range of antigen receptors (AgRs) through a process called V(D)J recombination, utilizing a limited number of genes while overcoming spatial and temporal challenges.
- Advances in technology have improved our understanding of the immunoglobulin heavy chain (Igh) locus structure and its regulatory elements, particularly focusing on recent sequencing methods and imaging studies that reveal how Igh undergoes dynamic changes during recombination.
- Key factors that regulate the Igh locus, such as transcription factors and structural proteins, are examined, along with exciting new findings related to the mechanisms of recombination, including Rag recombinase activity and an emerging phase separation model for compartment
