Early identification of a ward-based outbreak of using prospective multilocus sequence type-based Oxford Nanopore genomic surveillance.

Objective: To describe an outbreak of sequence type (ST)2 infection (CDI) detected by a recently implemented multilocus sequence type (MLST)-based prospective genomic surveillance system using Oxford Nanopore Technologies (ONT) sequencing.

Setting: Hemato-oncology ward of a public tertiary referral centre.

Methods: From February 2022, we began prospectively sequencing all isolated from inpatients at our institution on the ONT MinION device, with the output being an MLST.