FERN: is it possible to conduct a randomised controlled trial of intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregnancy - protocol for a prospective multicentre mixed-methods feasibility study.

Introduction: Selective fetal growth restriction (sFGR) in monochorionic twin pregnancy, defined as an estimated fetal weight (EFW) of one twin <10th centile and EFW discordance ≥25%, is associated with stillbirth and neurodisability for both twins. The condition poses unique management difficulties: on the one hand, continuation of the pregnancy carries a risk of death of the smaller twin, with a high risk of co-twin demise (40%) or co-twin neurological sequelae (30%). On the other, early delivery to prevent the death of the smaller twin may expose the larger twin to prematurity, with the associated risks of long-term physical, emotional and financial costs from neurodisability, such as cerebral palsy.

Diagnosis and management of selective fetal growth restriction in monochorionic twin pregnancies: A cross-sectional international survey.

Objective: To identify current practices in the management of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies.

Design: Cross-sectional survey.

Setting: International.

Timing of elective caesarean section at term: barriers to guidelines in practice.

The introduction of NICE guidelines in Britain on Caesarean Section provides valuable information on current research findings but little insight into how to implement the guidelines in practice. This is of particular concern when considering the best gestational age to deliver a baby by elective Caesarean Section as this study suggests a major shift in practice would be required to meet recommendations. Guidance on how to achieve recommended practice is ambiguous and requires further reflection by policy makers and practitioners alike.

A randomized trial using ultrasound to identify the high-risk fetus in a low-risk population.

Objective: To evaluate the effect of introducing two biophysical ultrasound examinations in a low-risk antenatal population. Scans were performed at 30-32 weeks' gestation and 36-37 weeks' gestation.

Methods: Scans assessed placental maturity, amniotic fluid volume, and estimated fetal weight.

Prostaglandin-induced activation of uterine contractility in pregnant rats does not involve potassium channels.

Objective: The uterus is a target for prostaglandins, especially at the end of gestation. Whether potassium channels are involved in the effect of prostaglandins is not clear. The aim of this study was to find out.